| 2021-09-01 | Morning Report: 49ers Cut Roster to 53 |
| 2021-09-01 | 49ers Sign 13 Players to Practice Squad |
| 2021-09-02 | Morning Report: 49ers Round Out Roster with 13-man Practice Squad |
| 2021-09-02 | WON Monthly Magazine September 2021 |
| 2021-09-03 | 49ers Sign Four Players to Practice Squad |
| 2021-09-04 | 49ers PREP selects Jakson Berman as the Week 1 Player of the Week |
| 2021-09-04 | The Most Intriguing 49ers Fantasy Options in 2021 |
| 2021-09-06 | 49ers Sign CB Josh Norman; Release CB Dontae Johnson |
| 2021-09-07 | Morning Report: NFL.com Analysts Predict Super Bowl LVI Matchups |
| 2021-09-08 | Morning Report: Bucky Brooks Reviews 49ers Two-QB System |
| 2021-09-08 | 49ers and Levi’s® Stadium Partner With Incogmeato® by MorningStar Farms® |
| 2021-09-08 | 49ers Announce 2021 Team Captains |
| 2021-09-08 | 49ers to Assess Trey Lance Before Sunday; Updates on Jalen Hurd, Others |
| 2021-09-09 | Morning Report: Kyle Shanahan Shares Injury Updates on Trey Lance |
| 2021-09-10 | Morning Report: Alex Mack Previews 2021 Season |
| 2021-09-10 | Who to Start, Who to Sit in 49ers Week 1 Matchup against the Lions |
| 2021-09-10 | Arranca la Temporada 2021 de 49ers en Detroit para Enfrentar a los Lions |
| 2021-09-10 | Energy Runs High in SF as 49ers Prepare for Week 1 vs. Lions |
| 2021-09-10 | Four Downs: Expectations for Jimmy Garoppolo, Nick Bosa vs. Lions |
| 2021-09-10 | 49ers Not Ruling Out Javon Kinlaw vs. Lions; Injury Report ahead of #SFvsDET |
| 2021-09-11 | 49ers PREP Selects Kaiden Hoapili as the Player of the Week |
| 2021-09-11 | 49ers PREP Selects Danny Calcagno as the Coach of the Week |
| 2021-09-11 | Josh Norman’s Potential Impact and the Goal That Brought Him to SF |
| 2021-09-11 | 49ers Announce Roster Moves ahead of #SFvsDET |
| 2021-09-12 | Ways to Watch and Listen to 49ers vs. Lions in Week 1 |
| 2021-09-12 | Trey Sermon, Josh Norman OUT vs. Lions; Full List of #SFvsDET Inactives |
| 2021-09-12 | Trey Lance Records His First NFL Touchdown vs. Lions |
| 2021-09-12 | 49ers Record Highest-Scoring First Half Under HC Kyle Shanahan |
| 2021-09-12 | Strong Start, Shakey Finish; Takeaways from 49ers Victory Over Lions |
| 2021-09-12 | Stats & Facts: 49ers Are 6-0 in Games Jimmy G Throws for Over 300 Yards |
| 2021-09-13 | Morning Report: Recapping 49ers at Lions Week 1 Matchup |
| 2021-09-13 | 49ers EDU Partners with SAP to Add Data Science to Curriculum |
| 2021-09-13 | Who Were the 49ers Top Performers in Week 1 Win vs. Lions? |
| 2021-09-13 | What the 49ers and Lions Had to Say Following Week 1 |
| 2021-09-13 | 49ers Confirm ACL Tear for Jason Verrett, Teammates React to Injury |
| 2021-09-13 | Kyle Shanahan Provides Updates on Raheem Mostert, Emmanuel Moseley and Others |
| 2021-09-14 | Former 49ers Linebacker Parys Haralson Passes Away |
| 2021-09-14 | Morning Report: Injury Updates on Verrett, Moseley and Mostert |
| 2021-09-14 | 49ers Activation Plan to Celebrate Latinx Heritage Month |
| 2021-09-14 | Primer Juego Primera Victoria |
| 2021-09-14 | Go-To Meals, O-Line Bonding and More; 7 Things We Learned From Alex Mack |
| 2021-09-14 | 49ers Sign Dre Kirkpatrick, Place Raheem Mostert and Jason Verrett on IR |
| 2021-09-14 | 49ers RB Elijah Mitchell is Up for Pepsi Zero Sugar Rookie of the Week |
| 2021-09-15 | 49ers Partner with Qumulo as New Data Storage Provider |
| 2021-09-15 | 2021 Power Rankings: How Do the 49ers Fare Following Week 1 Nail Biter? |
| 2021-09-15 | 49ers Claim RB Trenton Cannon Off Waivers |
| 2021-09-16 | Morning Report: Analysts Release Week 2 NFL Power Rankings |
| 2021-09-16 | Four Downs: Is What Jalen Hurts Did vs. Falcons in Week 1 For Real? |
| 2021-09-17 | Greenlaw ‘Re-Tweaks’ Groin; Al-Shaair Has Opportunity to ‘Show More’ |
| 2021-09-17 | Morning Report: Storylines to Watch in #SFvsPHI |
| 2021-09-17 | Elijah Mitchell's Fantasy Upside vs. Eagles; Who to Start/Sit in Week 2 |
| 2021-09-17 | 49ers Viaja a Philadelphia Para Enfrentar a Eagles |
| 2021-09-17 | Javon Kinlaw Questionable, Emmanuel Moseley Doubtful vs. Eagles |
| 2021-09-17 | 49ers to Lean on Trey Lance, Rookies as Eagles Present New Challenges |
| 2021-09-18 | 49ers PREP Selects Khai Taylor as the Player of the Week |
| 2021-09-18 | 49ers PREP Selects Greg Calcagno as the Coach of the Week |
| 2021-09-19 | Ways to Watch and Listen to 49ers vs. Eagles in Week 2 |
| 2021-09-19 | Josh Norman to Start, Trey Sermon to Make 49ers Debut vs. Eagles |
| 2021-09-19 | 49ers Escape Philly 2-0 in a Defensive Slugfest vs. Eagles |
| 2021-09-19 | Stats & Facts: 49ers Lead Two 90-Plus Yard TD Drives vs. Eagles |
| 2021-09-20 | What the 49ers and Eagles Had to Say Following Week 2 |
| 2021-09-20 | 49ers Defense and Special Teams Hold Strong for Second-Straight Win |
| 2021-09-20 | Morning Report: Recapping 49ers at Eagles in Week 2 |
| 2021-09-20 | Jimmy G Gets Down and Dirty in the Trenches to Secure 49ers Victory |
| 2021-09-20 | Who Were the 49ers Top Performers From 'Gritty' Win vs. Eagles? |
| 2021-09-20 | 49ers RBs ‘Have a Chance’; ‘Hopeful’ for Emmanuel Moseley in Week 3 |
| 2021-09-21 | Morning Report: Injury Updates on Moseley, Mitchell, Sermon and Others |
| 2021-09-21 | 75 for 75: First NFL Game |
| 2021-09-21 | No Trey Lance in Week 2? Kyle Shanahan Explains Why |
| 2021-09-21 | Otra Victoria en el Camino y Esta Vez Contra las Águilas |
| 2021-09-21 | 2021 Power Rankings: 49ers Sit as High as No. 2 Heading into Week 3 |
| 2021-09-21 | 49ers Sign RB Jacques Patrick; CB Release Dee Virgin |
| 2021-09-21 | Undefeated 49ers Have a Tough Road Ahead vs. Packers, NFC West |
| 2021-09-22 | Mitch Wishnowsky Named NFC Special Teams Player of the Week |
| 2021-09-22 | Morning Report: Power Rankings as 49ers Start Season 2-0 |
| 2021-09-22 | 75 for 75: First NFL Victory |
| 2021-09-22 | 49ers Announce 10-Year Commitment to Extend Social Justice Grant Program |
| 2021-09-22 | 49ers Sign RB Chris Thompson, DL Eddie Yarbrough to Practice Squad |
| 2021-09-23 | Morning Report: 49ers Sign Running Back Ahead of 'Sunday Night Football' |
| 2021-09-23 | 75 for 75: Bill Walsh’s First Draft |
| 2021-09-23 | 49ers Announce 75th Anniversary-Themed Fan Engagement Activations |
| 2021-09-23 | 49ers Will Look Vastly Different in Week 3 Rematch vs. Packers |
| 2021-09-24 | Morning Report: Everything You Need to Know Before #GBvsSF |
| 2021-09-24 | 75 for 75: Joe Montana’s First Touchdown Pass |
| 2021-09-24 | Are George Kittle, Deebo Samuel Fantasy Must-Starts vs. Packers? |
| 2021-09-24 | 49ers 'Holding Out Hope' for RB Elijah Mitchell; Packers LT Doubtful |
| 2021-09-24 | Four Downs: Can 49ers Overcome Early Injury Woes to Stay Undefeated? |
| 2021-09-25 | 49ers se Enfrenta a Packers en Horario Estelar Para su Primer Partido en Casa |
| 2021-09-25 | 49ers PREP Selects Adrian Navarro as the Player of the Week |
| 2021-09-25 | 49ers PREP Selects Michael Peters as Coach of the Week |
| 2021-09-25 | 49ers Announce Roster Moves Ahead of #GBvsSF |
| 2021-09-26 | Ways to Watch and Listen to 49ers vs. Packers in Week 3 |
| 2021-09-26 | Elijah Mitchell OUT, Trey Sermon Active; Packers Without Starting LT, CB |
| 2021-09-27 | The Good, The Bad and The Ugly from 49ers 1st Half vs. Packers |
| 2021-09-27 | Trey Lance Makes 2nd Appearance of the Season for TD |
| 2021-09-27 | 49ers Rally Too Late as SF Suffers First Loss of Season vs. Packers |
| 2021-09-27 | Welcome to the NFL, Trey Sermon; Rookie RB Records 1st-Career TD |
| 2021-09-27 | Morning Report: Recapping 'Sunday Night Football' vs. the Packers |
| 2021-09-27 | What the 49ers and Packers Had to Say Following Week 3 |
| 2021-09-27 | George Kittle, Trent Williams Near Top of their Positions Through Week 3 |
| 2021-09-27 | Josh Norman Suffers Lung Contusion, George Kittle is ‘Day-to-Day’ |
| 2021-09-28 | Morning Report: Injury Updates on Kittle, Norman, Mitchell, Williams |
| 2021-09-28 | 75 for 75: More Than The Catch |
| 2021-09-28 | En Los Últimos Segundos San Francisco Sufre Su Primera Derrota |
| 2021-09-28 | 2021 Power Rankings: Does Loss to Packers Affect 49ers Position? |
| 2021-09-29 | Morning Report: 49ers Power Rankings Heading into Week 4 vs. Seattle |
| 2021-09-29 | 75 for 75: Plummer Plows, Woodall Wows |
| 2021-09-29 | 49ers Look to Bounce Back Against Division Rivals |
| 2021-09-29 | 49ers Sign CB Buster Skrine; Open IR Practice Window for Two Players |
| 2021-09-30 | Mitch Wishnowsky Earns First-Career NFC Special Teams Player of the Month Honor |
| 2021-09-30 | Morning Report: Lance Lone 1st Round QB to Earn 'A' Grade in Week 3 |
| 2021-09-30 | Ways to Watch and Listen to 49ers vs. Seahawks in Week 4 |
| 2021-09-30 | 75 for 75: The Pick at the Stick |
| 2021-09-30 | Jimmie Ward Evaluates 49ers Defensive Rookies in the Secondary |
| 2021-09-30 | Trent Williams Named Week 3 Recipient of NFL Way to Play Award |
| 2021-09-30 | Four Downs: Can 49ers Exploit Seattle's 26th-Ranked Passing Defense? |
