| 2021-04-01 | Morning Report: Pro Football Focus' Updated Draft Big Board |
| 2021-04-01 | 49ers Hire Christina Jefferson as Director of Diversity, Equity, and Inclusion |
| 2021-04-01 | WON Monthly Magazine April 2021 |
| 2021-04-01 | 49ers Re-sign CB Jason Verrett |
| 2021-04-01 | 49ers, SportTechie Partner to Host Fifth-Annual Horizon Summit Online |
| 2021-04-02 | Morning Report: How Each QB Prospect Fits into Kyle Shanahan's Offense |
| 2021-04-03 | 49ers PREP Selects Demetrius Freeney as Week 2 Player of the Week |
| 2021-04-03 | 49ers PREP Selects Jason Miller as Week 2 Coach of the Week |
| 2021-04-05 | Morning Report: PFF's Pros and Cons for Every QB Prospect |
| 2021-04-05 | 2021 Mock Draft Monday 7.0: Which QB is the Best Fit for 49ers at No. 3? |
| 2021-04-06 | Morning Report: Analysts Predict All QBs in Latest 49ers Mock Draft |
| 2021-04-07 | Morning Report: NFL Draft Quarterback Superlatives |
| 2021-04-07 | Tenured Women of the 49ers Front Office: Carri Kimball |
| 2021-04-07 | 49ers Sign QB Nate Sudfeld |
| 2021-04-08 | Morning Report: 49ers Sign Quarterback to One-Year Deal |
| 2021-04-08 | Senior Bowl to Induct Joe Staley and Four Others into Hall of Fame |
| 2021-04-09 | Morning Report: Joe Staley Earns Senior Bowl HOF Honor |
| 2021-04-09 | 49ers PREP Selects Ben Ballard as Week 3 Coach of the Week |
| 2021-04-09 | 49ers PREP Selects Max Griffiths as Week 3 Player of the Week |
| 2021-04-09 | Free Agent Facts: Wide Receiver Mohamed Sanu |
| 2021-04-09 | Nick Bosa Gives an Encouraging Peek into Offseason Rehab |
| 2021-04-12 | Morning Report: Nick Bosa Shares Workout Video |
| 2021-04-13 | Morning Report: NFL's Chad Reuter Projects 49ers First Two Draft Picks |
| 2021-04-13 | Is the Next Deebo Samuel in This Year's Draft Class? |
| 2021-04-13 | Daniel Brunskill Signs One-Year Tender; 49ers Waive TE Chase Harrell |
| 2021-04-14 | Free Agent Facts: Defensive Lineman Zach Kerr |
| 2021-04-14 | Morning Report: Could 49ers Target WR in Round 2? |
| 2021-04-14 | 49ers Expand HS Sports Coverage to Sacramento with Sac-Hi Sports |
| 2021-04-15 | Morning Report: NFL.com Says 'Not to Doubt' Alex Mack in 2021 |
| 2021-04-15 | 49ers Launch Virtual Lesson Series For K-8 Students and Educators |
| 2021-04-15 | Free Agent Facts: Wide Receiver Trent Sherfield |
| 2021-04-16 | Morning Report: Mike McDaniel Talks New Job as 49ers OC |
| 2021-04-17 | 49ers PREP Selects Jake Ripp as Week 4 Player of the Week |
| 2021-04-17 | Free Agent Facts: Safety Tavon Wilson |
| 2021-04-19 | Morning Report: Biggest Roster Changes Around the NFC West |
| 2021-04-20 | Free Agent Facts: Linebacker Nathan Gerry |
| 2021-04-20 | Morning Report: Alex Smith Hangs Up Cleats After 16-year Career |
| 2021-04-20 | 6 Potential Outcomes for 49ers No. 3 Overall Pick |
| 2021-04-21 | Morning Report: Examining Every Scenario for 49ers at No. 3 |
| 2021-04-21 | NFL to Release 49ers 2021 17-Game Schedule May 12 |
| 2021-04-21 | 49ers Sign RB Wayne Gallman Jr. |
| 2021-04-22 | Morning Report: NFL Sets Date for the 2021 Schedule Release |
| 2021-04-22 | NFL Network and ESPN Analysts Share Final 49ers Draft Predictions |
| 2021-04-23 | Morning Report: Draft Analysts Predict Third-Overall Pick |
| 2021-04-23 | How Kyle Shanahan's Past Success Offers Insights to No. 3 Overall |
| 2021-04-23 | 49ers Sign Two Defensive Linemen to One-year Deals |
| 2021-04-24 | 49ers PREP Selects Eric Rado as Week 5 Coach of the Week |
| 2021-04-24 | 49ers PREP Selects Josh Baughman as Week 5 Player of the Week |
| 2021-04-26 | Morning Report: Ian Rapoport Gives His Take on No. 3 Pick |
| 2021-04-26 | 49ers Celebrate 75th Anniversary Season |
| 2021-04-26 | Transcripts: John Lynch and Kyle Shanahan Speak Before the 2021 NFL Draft |
| 2021-04-26 | How to Watch the 2021 NFL Draft: A Guide for 49ers Faithful |
| 2021-04-27 | 2021 Mock Draft Monday 8.0: Final QB Projections Before Round 1 |
| 2021-04-27 | 49ers Celebran su Aniversario Número 75 esta Temporada |
| 2021-04-27 | Morning Report: Analysts Reveal Final Predictions Before the Draft |
| 2021-04-27 | Faithful Member Spotlight: Shirley Caracci |
| 2021-04-28 | 49ers Mailbag: What are San Francisco's Immediate Draft Needs? |
| 2021-04-28 | Morning Report: Could 49ers Fans Expect a Surprise at No. 3 Overall? |
| 2021-04-28 | Faithful Time Machine: A Draft That Built A Dynasty |
| 2021-04-28 | 49ers Re-Sign OL Tom Compton |
| 2021-04-28 | History Says Shanahan, Lynch Not Afraid to Make Big Plays in NFL Draft |
| 2021-04-28 | Where Does Daniel Jeremiah Have 49ers QB Options Ranked? |
| 2021-04-29 | Morning Report: 2021 NFL Draft Edition |
| 2021-04-30 | 49ers Select QB Trey Lance with the No. 3 Pick in the 2021 NFL Draft |
| 2021-04-30 | Transcripts: John Lynch and Kyle Shanahan Review Day 1 of the 2021 Draft |
| 2021-04-30 | 49ers Players, Front Office and Media React to First Round Selection |
| 2021-04-30 | Transcripts: Trey Lance Introductory Press Conference |
| 2021-04-30 | Morning Report: Everything You Missed from Day 1 of the Draft |
| 2021-04-30 | How 49ers Surprised Trey Lance, Entire League with No. 3 Overall Pick |
| 2021-04-30 | Top Players Available for Day 2 of the Draft to Fit 49ers Needs |
| 2021-04-30 | Experts Grade 49ers First Round Pick, Trey Lance |
| 2021-04-30 | 49ers Seleccionan al QB Trey Lance en la Primera Ronda del NFL Draft |
| 2021-04-30 | NFL Analysts Evaluate 49ers Selection of Trey Lance No. 3 Overall |
