The 49ers complete their two-game road trip with a clash against the NFC South champion Saints. Here's everything you need to know.

Top quotes from both locker rooms following the 49ers last-second loss to the Ravens. 

The 49ers travel to take on the AFC North-leading Baltimore Ravens. Here's everything you need to know.

Top quotes from both locker rooms following the 49ers 37-8 victory over the Green Bay Packers.

Here are five key matchups that could decide the 49ers Sunday night battle against the NFC North-leading Packers. 

The 49ers take on the Packers in primetime at Levi's® Stadium. Here's everything you need to know.

Top quotes from both locker rooms following the 49ers 36-26 victory over the Arizona Cardinals.

Top quotes from both locker rooms following the 49ers loss to the Seahawks in Week 10. 

Here are five key matchups that could decide the 49ers Monday night battle against the divisional rival Seahawks. 

Let's take a look at the stats that have been key to the 49ers undefeated start.

Top quotes from both locker rooms following the 49ers 28-25 victory in Week 9. 

Here are five key matchups that could decide the NFC West divisional showdown between San Francisco and Arizona. 

The 49ers return home after a two-game road trip to host the Carolina Panthers. Here's everything you need to know.

Top quotes from both locker rooms following the 49ers 9-0 victory in Week 7. 

After six weeks of football, find out where Pro Football Focus lists the 49ers defense. 

The 49ers travel to Washington to take on the Redskins in Week 7. Here's everything you need to know about the upcoming matchup. 

Here are five key matchups that could decide the 49ers divisional clash with the Rams. 

Top quotes from both locker rooms following the 49ers 31-3 victory in Week 5. 

Here are five key matchups that could decide the 49ers Monday night battle against the Browns. 

The 49ers return from the bye week with a clash against the Cleveland Browns on "Monday Night Football." Here's everything you need to know.

Here are five key matchups that could decide the 49ers home opener against Pittsburgh. 

The 49ers return to Levi's® Stadium for the home opener against the Pittsburgh Steelers in Week 3. Here's everything you need to know about the upcoming matchup. 

Jeff Deeney provided grades for the 49ers top performers in Week 2 and three were named to Pro Football Focus 'Team of the Week'.

The 49ers travel to Tampa Bay to take on the Buccaneers to open up the regular season. Here's everything you need to know about the upcoming matchup. 

Here are five key matchups that could decide the 49ers season opener in Tampa Bay.

Take a look at the reactions from members of the 49ers as they unboxed their personalized cleats for the 'My Cause My Cleats' campaign.

Buckner discussed the challenges of containing Ravens quarterback Lamar Jackson and praised his teammates for "fighting until the very end."

The 49ers teamed up with Martha’s Kitchen to serve a Thanksgiving dinner to those in need.

Listen in as DeForest Buckner was wired for sound during the 49ers 37-8 victory over the Green Bay Packers on "Sunday Night Football". You can vote Buckner into the Pro Bowl at 49rs.co/probowlvote20.

Former NFL defensive back DeAngelo Hall examined the Coaches Film to see how the 49ers defense gave Packers quarterback Aaron Rodgers trouble in Week 12 on "Sunday Night Football."

Buckner reviewed the performance of the 49ers defense on "Sunday Night Football" and praised Arik Armstead for his breakout season.

Watch all the top highlights from San Francisco's tenth victory of the season.

The defense holds the Packers running back to no gain on 4th down. You can vote the 49ers defense into the Pro Bowl at 49rs.co/probowlvote20.

Buckner discussed the challenges of containing Kyler Murray and praised Arik Armstead's breakout season.

Watch all the top highlights from San Francisco's ninth victory of the season.

Buckner analyzed the defense's best plays from the Week 10 "Monday Night Football" matchup against the Seattle Seahawks.

Buckner joins Keiana Martin to discuss the team's mindset following the loss against Seattle and cleaning up the defensive mistakes from Week 9 in Arizona.

Watch K'Waun Williams sack Russell Wilson, Fred Warner force a fumble and DeForest Buckner scoop the ball up and score his first-career touchdown against the Seattle Seahawks from every angle with True View technology powered by Intel. Multiple high-resolution cameras render thrilling, slow-motion replays and highlight reels.

Buckner praised his teammates relentless attitude against the Seahawks and gave a play-by-play of his fumble recovery score.

Watch the top plays from the Week 10 "Monday Night Football" matchup against the Seattle Seahawks.

After K'Waun Williams strip-sacked Russell Wilson, Warner forced out the loose ball, Buckner recovered it and took it all the way for a 49ers touchdown.

Williams knocks the ball loose and Buckner recovered.

Let's rewind and review the best Mic'd Up soundbites from the team's undefeated first half of the season.

Buckner broke down the 49ers defensive performance during the team's 28-25 win over the Arizona Cardinals.

NFL Network's Brian Baldinger analyzed the performance by the 49ers defensive front in the team's 51-13 victory over the Panthers in Week 8.

Buckner reviewed the defense’s performance following the team's 51-13 victory over Carolina and discussed the work the 49ers defensive line put in during the offseason.

Laken Tomlinson and Keiana Martin broke down 49ers defensive performance against the Redskins in Week 7.

The San Francisco 49ers are taking things back to 1994 with their throwback inspired alternate uniforms.

The 49ers defensive lineman reviewed the defense's Week 7 shutout against the Washington Redskins.

NFL Network's Steve Wyche caught up Buckner after the 49ers win over the Los Angeles Rams in Week 6.