| WR | Mike Evans | Jacob Cowing Jordan Watkins | Will Pauling Trenton Irwin | |
| LT | Trent Williams | Vederian Lowe | Enrique Cruz Jr. | |
| LG | Robert Jones | Carver Willis | | |
| C | Jake Brendel | Drake Nugent | Brett Toth | Doug Kramer Jr. |
| RG | Dominick Puni | Connor Colby | Nick Zakelj | |
| RT | Colton McKivitz | Austen Pleasants | Brandon Parker | Isaac Alarcon |
| TE | George Kittle | Jake Tonges Luke Farrell | Hayden Rucci Brayden Willis | Khalil Dinkins |
| WR | Demarcus Robinson Deebo Samuel Sr. | Christian Kirk De'Zhaun Stribling | Malik Turner | Wesley Grimes KhaDarel Hodge |
| RB | Christian McCaffrey | Jordan James Kaelon Black | Sincere McCormick | Khalil Herbert |
| FB | Kyle Juszczyk | | | |
| QB | Brock Purdy | Mac Jones | Kurtis Rourke | Adrian Martinez |
