Here are five key matchups that could decide the 49ers clash with the NFC South champion New Orleans Saints.

The 49ers complete their two-game road trip with a clash against the NFC South champion Saints. Here's everything you need to know.

Top quotes from both locker rooms following the 49ers last-second loss to the Ravens. 

Here are five key matchups that could decide the 49ers clash with the AFC North-leading Ravens. 

Top quotes from both locker rooms following the 49ers 37-8 victory over the Green Bay Packers.

More on the weekly honor and how to vote following the 49ers comeback victory against the Cardinals.

Top quotes from both locker rooms following the 49ers 36-26 victory over the Arizona Cardinals.

Here are five key matchups that could decide the 49ers and Cardinals second contest of the season. 

Let's take a look at the stats that have been key to the 49ers undefeated start.

Kyle Shanahan provided injury updates ahead of the 49ers Week 7 matchup against the Redskins.

Take a look at six standouts in the 49ers Monday night clash with the Denver Broncos. 

It was a slow start for Jimmy Garoppolo and the 49ers offense in the 24-15 win over the Broncos.

The top notes and observations from the 49ers and Broncos final joint practice ahead of Monday's preseason contest.

Top notes and observations from the 49ers 13th training camp practice.

Take a look at five newcomers that stood out in the 49ers preseason opener against the Cowboys.

The 49ers held their final practice ahead of their preseason opener against Dallas on Saturday.

San Francisco's offense highlighted a physical session on Wednesday.

The 49ers closed the weekend with an evenly-matched practice ahead of a much needed day off on Monday.

San Francisco's pass catchers "had a day" during Saturday's session.

Notes and takeaways from the 49ers first padded practice of camp.

Three 49ers rookies highlighted the team's first training camp practice of the year.

With Bosa and Samuel under contract, the 49ers have signed all eight of their 2019 draft picks.

Shanahan addressed the backup quarterback competition, injury updates, his early impressions of Nick Bosa and more.

A rundown of all the top happenings at Wednesday's practice.

South Carolina's head coach had nothing but positive remarks for his former pupil.

Watch the top plays from the Week 13 matchup against the Baltimore Ravens.

Garoppolo hit Samuel for a 33-yard score to cap off the 49ers opening drive. You can vote Garoppolo and Samuel into the Pro Bowl at 49rs.co/probowlvote20.

Watch Deebo Samuel's touchdown against the Green Bay Packers from every angle with True View technology powered by Intel. Multiple high-resolution cameras render thrilling, slow-motion replays and highlight reels.

DL Arik Armstead, DB Jimmie Ward, T Mike McGlinchey, S Jaquiski Tartt, WR Deebo Samuel and CB Ahkello Witherspoon discussed the overall team performance in the 37-8 victory over the Green Bay Packers.

Watch all the top highlights from San Francisco's tenth victory of the season.

Jimmy Garoppolo hit Samuel in stride for the 42-yard score. You can vote Garoppolo and Samuel into the Pro Bowl at 49rs.co/probowlvote20.

RB Jeff Wilson Jr., LB Fred Warner, TE Ross Dwelley, T Mike McGlinchey, WR Deebo Samuel and DL Damontre Moore discussed pivotal plays which secured the team's 36-26 win over the Cardinals.

Watch all the top highlights from San Francisco's ninth victory of the season.

Watch every catch from Samuel's eight reception, 134-yard day against the Arizona Cardinals in Week 11.

Jaquiski Tartt, Deebo Samuel, Kyle Juszczyk and Dre Greenlaw recap the 27-24 loss to the Seattle Seahawks on "Monday Night Football."

Watch the top plays from the Week 10 "Monday Night Football" matchup against the Seattle Seahawks.

Jimmy Garoppolo connected with Samuel over the middle for a 30-yard pickup.

Peach or barf. Strawberry-banana smoothie or dead fish. 49ers players took on a round of Bean Boozled and ate your typical, and not so typical, jelly bean flavors in the process.

Samuel took the handoff and followed his blockers into the end zone.

Watch the top highlights from the 49ers victory over the Pittsburgh Steelers in Week 3.

Baldinger analyzed San Francisco's Week 2 film to show how the 49ers managed to compile six pass plays of 20 yards or more in the team's 41-17 victory over the Bengals.

Watch the top highlights from the 49ers victory over the Cincinnati Bengals in Week 2.

Jimmy Garoppolo connected with an open Samuel in the end zone for the team's fourth touchdown of the day.

The rookie wide receiver reviewed his play during the team’s Week 1 win over the Buccaneers and highlighted the selflessness of the 49ers receiving corps.

Watch the top highlights from the 49ers victory over the Tampa Bay Buccaneers in Week 1.

The competition continues for Round 3. See who comes out victorious as Kendrick Bourne takes on defending champ Deebo Samuel in a 49ers vs. 49ers Madden competition.

Raheem Mostert, Deebo Samuel, Mitch Wishnowsky and Jaquiski Tartt discussed the team's comeback win over the Denver Broncos.

Samuel ran around edge for 45 yards to set up a 49ers touchdown in the 3rd quarter vs. the Denver Broncos

Richard Sherman, George Kittle, Marquise Goodwin and more shared secrets and competed in challenges during a round of “49ers Truth or Dare.”

Samuel caught a 45-yard pass from C.J. Beathard late in the third quarter against the Dallas Cowboys to set up a 49ers touchdown.