San Francisco 49ers QB1 Trey Lance exited Sunday's contest early with an ankle injury. The second-year quarterback was injured on the second of the 49ers second offensive series. No. 5 made contact with two Seattle defenders on a run up the middle and was carted off the field. He was later ruled out for the remainder of the game.
Lance was replaced with backup quarterback Jimmy Garoppolo at the end of the first quarter.