The San Francisco 49ers announced the following roster moves.

Step inside Weeks 16 and 17 for the San Francisco 49ers matchups against the Indianapolis Colts and Chicago Bears, presented by Toyota.

Go on the field with the San Francisco 49ers players during the team's 48-27 victory over the Indianapolis Colts.

San Francisco 49ers quarterback Brock Purdy was named NFC Offensive Player of the Week after the team's Week 16 win over the Indianapolis Colts.

Take a look at key stats from the San Francisco 49ers Week 16 matchup vs. the Indianapolis Colts.

View postgame photos following the San Francisco 49ers Week 16 matchup vs. the Indianapolis Colts.

View photos of 49ers fans during the team's Week 16 game against the Indianapolis Colts.

Get an inside view of the 49ers locker room following the team's Week 16 win over the Colts presented by Ticketmaster.

San Francisco 49ers QB Brock Purdy, TE George Kittle, RB Christian McCaffrey, T Trent Williams, and LB Dee Winters highlighted team chemistry, preparation, and the importance of staying focused as the 49ers look ahead to the playoffs.

San Francisco 49ers DL C.J. West reflected on his first-career sack and shared his reaction to the 49ers "Monday Night Football" win over the Indianapolis Colts, presented by Lexus.

The San Francisco 49ers finished their Week 16 "Monday Night Football" contest with a 48-27 win over the Indianapolis Colts at Lucas Oil Stadium.

San Fransisco TE George Kittle marked seven receptions for 115 yards and a TD vs. the Indianapolis Colts on "Monday Night Football."

San Francisco 49ers QB Brock Purdy threw a career-high five touchdown passes in his team's Week 16 win over the Indianapolis Colts.

San Francisco 49ers RB Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns Monday Night vs. the Indianapolis Colts.

Watch the best plays by the San Francisco 49ers against the Indianapolis Colts in Week 16 of the 2025 NFL season.

San Francisco 49ers head coach Kyle Shanahan reflected on the 49ers journey this season, emphasizing consistency, leadership, and the players' ability to overcome injuries and adversity to secure a crucial win.

View game photos from the San Francisco 49ers Week 16 matchup vs. the Indianapolis Colts at Lucas Oil Stadium.

San Francisco DL Alfred Collins sacks Colts QB Philip Rivers, forcing a fumble that results in a 15-yard loss in the team's Week 16 matchup.

San Francisco 49ers RB Christian McCaffrey catches a 9-yard touchdown pass from QB Brock Purdy, marking his second TD of the night.

San Francisco 49ers RB Christian McCaffrey raced out of the backfield for a 24-yard gain, marking his longest carry of the 2025 season.

San Francisco QB Brock Purdy throws his fourth touchdown of the night to WR Jauan Jennings.

San Francisco 49ers QB Brock Purdy delivered a precise 21-yard pass to WR Jauan Jennings as the 49ers move the ball downfield against Indianapolis.

San Francisco 49ers QB Brock Purdy completed a 23-yard pass to WR Skyy Moore in the team's Week 16 matchup.

San Francisco DT C.J. West bursts through the line to sack Colts QB Philip Rivers for an 8-yard loss.

San Francisco 49ers TE George Kittle secured an 11-yard touchdown reception from QB Brock Purdy, giving the 49ers momentum against Indianapolis.

San Francisco 49ers RB Christian McCaffrey flashed his quickness on an 18-yard rush as the 49ers move the chains.

San Francisco 49ers RB Christian McCaffrey catches a 2-yard touchdown pass from QB Brock Purdy in the team's Week 16 matchup against the Indianapolis Colts.

San Francisco 49ers TE Jake Tonges recovered a fumble after Indianapolis Colts RB Ameer Abdullah lost control, giving the 49ers a key takeaway.

San Francisco 49ers QB Brock Purdy connected with WR Demarcus Robinson on a 22-yard touchdown in the team's Week 16  matchup against the Indianapolis Colts.

View pregame photos from the San Francisco 49ers Week 16 matchup vs. the Indianapolis Colts at Lucas Oil Stadium.

Take a look at players who have been ruled out for the San Francisco 49ers Week 16 "Monday Night Football" matchup versus the Indianapolis Colts.

View photos as the team arrives at the locker room for their Week 16 matchup against the Indianapolis Colts, presented by Levi's®.

The San Francisco 49ers announced the following roster moves

Check out some of the top photos as the 49ers fly to Indianapolis to take on the Colts, presented by United Airlines.

San Francisco 49ers head coach Kyle Shanahan addressed WR Ricky Pearsall's status and shared the latest injury updates as the team prepares for Monday's matchup against the Indianapolis Colts.

The San Francisco 49ers released their latest injury updates headed into the Week 16 "Monday Night Football" contest versus the Indianapolis Colts.

Take a look at the standout moments from 49ers practice as they prepare for their Week 16 matchup with the Indianapolis Colts.

San Francisco 49ers team reporter Briana Jeannel addresses fans' biggest questions ahead of Week 16 vs. the Indianapolis Colts.

Defensive coordinator Robert Saleh and offensive coordinator Klay Kubiak discussed the team's matchup prep, highlighted key contributions from veterans and young players, and shared how the 49ers are staying focused on controlling their playoff run.

Broadcast and streaming information for the San Francisco 49ers Week 16 'Monday Night Football' matchup against the Indianapolis Colts at Lucas Oil Stadium.

As the San Francisco 49ers prepare for a crucial Week 16 'Monday Night Football' showdown against the Indianapolis Colts, safety Malik Mustapha is hitting his stride at just the right time.

San Francisco 49ers TE George Kittle, RB Christian McCaffrey, and DL Keion White discussed the energy inside the locker room, shared the importance of December games, and described the team's mindset as the 49ers continue their push towards the postseason.

San Francisco 49ers head coach Kyle Shanahan highlighted Indianapolis' run defense, reflected on overcoming injuries, and emphasized a one-week-at-a-time approach with the playoffs on the line.

Watch the NFL's official Week 16 game preview for Indianapolis Colts vs. San Francisco 49ers.