San Francisco 49ers vs. Indianapolis Colts Game Preview | Week 16

NFL Insider Tom Pelissero breaks down the playoff clinching scenarios around the NFL in Week 16. San Francisco 49ers have a shot to clinch on "Monday Night Football" with a win.

Watch the NFL's official Week 16 game preview for Indianapolis Colts vs. San Francisco 49ers.

Join San Francisco 49ers LB Dee Winters on the Microsoft Surface as he breaks down his biggest plays, presented by Copilot.

Go on the field with the San Francisco 49ers players during the team's 37-24 victory over the Tennessee Titans.

Listen in as San Francisco 49ers Head Coach Kyle Shanahan was wired for sound during the team's Week 15 matchup against the Tennessee Titans.

Jesús Zárate y Carlos Yustis analizan todo sobre el partido de la Semana 15 entre los San Francisco 49ers y los Tennessee Titans, así como el camino a recorrer el resto de la temporada para asegurar un lugar en los Playoffs.

The 49ers Foundation and our 49ers PREP team partnered with legacy beneficiary Fresh Lifelines for Youth (FLY) to welcome in youth from the William F. James Boys Ranch and FLY's at-risk youth to Levi's® Stadium.

Sergeant First Class Takumi Abe visited from Hawaii and spent time with TE George Kittle at Levi's® Stadium, creating a memorable exchange before the Tennessee Titans game.

Miguel Pasquel nos comparte su opinión sobre la décima victoria de los San Francisco 49ers en la temporada al vencer por 37 a 24 a los Tennessee Titans.

Get an inside view of the 49ers locker room following the team's Week 15 win over the Titans presented by Ticketmaster.

Enrique Zárate Jr. y Jesús Zárate analizan todo lo que ocurrió en el partido entre los San Francisco 49ers y los Tennessee Titans, que terminó con marcador de 24-37, con el que se consigue la décima victoria de la campaña. Además, una entrevista especial con el novato de la línea ofensiva, Connor Colby.

San Francisco 49ers WR Jauan Jennings reflected on scoring touchdowns on his first two receptions, praised QB Brock Purdy's performance, and shared his message to the Faithful following the 49ers Week 15 win over the Tennessee Titans, presented by Lexus.

San Francisco 49ers QB Brock Purdy, TE George Kittle, and RB Christian McCaffrey broke down big plays, celebrated standout moments, and reflected on the collective effort that powered the 49ers to victory against the Titans

San Francisco 49ers head coach Kyle Shanahan discussed QB Brock Purdy's standout performance, reflected on key moments from the game, and shared insights on the team's dynamics and player contributions.

Check out the San Francisco 49ers biggest moments and game-changing plays from their Week 15 win over the Tennessee Titans.

Watch the best plays from San Francisco 49ers QB Brock Purdy, who threw three touchdown passes and added 44 rushing yards in the team's Week 15 win over the Tennessee Titans.

The San Francisco 49ers hosted a special halftime ceremony on Sunday to celebrate the induction of three-time Super Bowl champion Brent Jones into the Edward J. DeBartolo Sr. San Francisco 49ers Hall of Fame.

San Francisco 49ers QB Brock Purdy scrambled past Tennessee Titans defenders for a 26-yard gain.

San Francisco 49ers QB Brock Purdy connected with TE George Kittle for a 1-yard touchdown against the Tennessee Titans.

San Francisco 49ers WR Ricky Pearsall found space over the middle and turned it into a 38-yard gain in the team's Week 15 matchup.

San Francisco 49ers WR Jauan Jennings hauled in a 13-yard touchdown pass, marking his second score of the game against the Tennessee Titans.

San Francisco 49ers QB Brock Purdy's quick throw to TE George Kittle resulted in a 24-yard gain in the team's Week 15 matchup.

San Francisco 49ers QB Brock Purdy rolled out and fired a strike to WR Demarcus Robinson for a big gain to spark the drive.

San Francisco 49ers RB Christian McCaffrey capped the drive with a one-yard rushing touchdown against the Tennessee Titans.

San Francisco 49ers QB Brock Purdy connected with WR Jauan Jennings for a four-yard touchdown in the team's Week 15 matchup against the Tennessee Titans.