McCaffrey's 15th TD of 2025 Puts 49ers Ahead of Colts

San Francisco QB Brock Purdy throws his fourth touchdown of the night to WR Jauan Jennings.

San Francisco 49ers QB Brock Purdy delivered a precise 21-yard pass to WR Jauan Jennings as the 49ers move the ball downfield against Indianapolis.

San Francisco 49ers QB Brock Purdy completed a 23-yard pass to WR Skyy Moore in the team's Week 16 matchup.

San Francisco DT C.J. West bursts through the line to sack Colts QB Philip Rivers for an 8-yard loss.

San Francisco 49ers TE George Kittle secured an 11-yard touchdown reception from QB Brock Purdy, giving the 49ers momentum against Indianapolis.

San Francisco 49ers RB Christian McCaffrey flashed his quickness on an 18-yard rush as the 49ers move the chains.

San Francisco 49ers RB Christian McCaffrey catches a 2-yard touchdown pass from QB Brock Purdy in the team's Week 16 matchup against the Indianapolis Colts.

San Francisco 49ers TE Jake Tonges recovered a fumble after Indianapolis Colts RB Ameer Abdullah lost control, giving the 49ers a key takeaway.

San Francisco 49ers QB Brock Purdy connected with WR Demarcus Robinson on a 22-yard touchdown in the team's Week 16  matchup against the Indianapolis Colts.

El Monday Night Football ha llegado y los San Francisco 49ers están listos para enfrentarse de visita a los Indianapolis Colts. Jesús Zárate y Carlos Yustis nos comparten las claves para este partido.

San Francisco 49ers QB Brock Purdy surprised families with incredible holiday gifts, including Toyota vehicles, Rivalries jerseys, and tickets to an upcoming 49ers game, creating unforgettable moments for all, presented by Toyota.

Flag football is taking shape in U.A.E. schools, helping students develop skills, teamwork, and confidence on the field.

Jesús Zárate nos comparte el estado del roster después de los entrenamientos de la Semana 16 en preparación del partido en lunes por la noche en contra de los Indianapolis Colts.

San Francisco 49ers head coach Kyle Shanahan addressed WR Ricky Pearsall's status and shared the latest injury updates as the team prepares for Monday's matchup against the Indianapolis Colts.

El partido de la Semana 16 será en Lunes por la Noche cuando los San Francisco 49ers visiten a los Indianapolis Colts, y Miguel Pasquel tiene las claves para salir con la victoria en este encuentro.

San Francisco 49ers WR Jauan Jennings, DB Deommodore Lenoir, and S Jason Pinnock discussed the race for the NFC West's top seed and looked ahead to "Monday Night Football" against the Indianapolis Colts.

San Francisco 49ers QB Brock Purdy shared insights on his preparation that goes into each game, reflected on the importance of staying focused on executing the offense, and discussed the team's approach to tempo, decision-making, and maintaining discipline in high-pressure situations.

Three-time Super Bowl Champion, former San Francisco 49ers tight end Brent Jones joined "You've Got Mail" presented by Delta Dental to discuss his induction to the Edward J. DeBartolo Sr. 49ers Hall of Fame, share memories from the 49ers Super Bowl dynasty, and more.

Defensive coordinator Robert Saleh and offensive coordinator Klay Kubiak discussed the team's matchup prep, highlighted key contributions from veterans and young players, and shared how the 49ers are staying focused on controlling their playoff run.

Offensive lineman Jake Brendel sits down for an episode of "Cut Different" presented by Gillette for a fresh cut and real talk on humble beginnings, family, motivation, and becoming a professional athlete.

Quedan tres partidos en la temporada para los San Francisco 49ers y el camino final comienza este lunes por la noche cuando visiten a los Indianapolis Colts. Miguel Pasquel y Alfredo Gutiérrez comentan todo lo que hay que saber previo a este duelo importante.

JJ Stankevitz from the Indianapolis Colts previews Week 16 "Monday Night Football", with one-on-one interviews featuring San Francisco 49ers DL Clelin Ferrell and WR Jauan Jennings.

San Francisco 49ers TE George Kittle, RB Christian McCaffrey, and DL Keion White discussed the energy inside the locker room, shared the importance of December games, and described the team's mindset as the 49ers continue their push towards the postseason.

San Francisco 49ers head coach Kyle Shanahan highlighted Indianapolis' run defense, reflected on overcoming injuries, and emphasized a one-week-at-a-time approach with the playoffs on the line.

Estamos a un paso de las finales en las ligas de Fantasy Football y por eso no hay que bajar la guardia. Miguel Pasquel tiene los tips para consolidar el triunfo en las semifinales, y además, los picks de la semana incluyendo el último duelo como visitante de los San Francisco 49ers en la temporada regular cuando viajen a Indianapolis para enfrentarse a los Colts.