Christian McCaffrey Adds Second TD to 49ers 'MNF' Lead

San Francisco 49ers DL C.J. West reflected on his first-career sack and shared his reaction to the 49ers "Monday Night Football" win over the Indianapolis Colts, presented by Lexus.

San Fransisco TE George Kittle marked seven receptions for 115 yards and a TD vs. the Indianapolis Colts on "Monday Night Football."

San Francisco 49ers QB Brock Purdy threw a career-high five touchdown passes in his team's Week 16 win over the Indianapolis Colts.

San Francisco 49ers RB Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns Monday Night vs. the Indianapolis Colts.

Watch the best plays by the San Francisco 49ers against the Indianapolis Colts in Week 16 of the 2025 NFL season.

San Francisco 49ers head coach Kyle Shanahan reflected on the 49ers journey this season, emphasizing consistency, leadership, and the players' ability to overcome injuries and adversity to secure a crucial win.

San Francisco 49ers LB Dee Winters intercepted Indianapolis Colts QB Philip Rivers and returned it 74 yards for a pick-six.

San Francisco DL Alfred Collins sacks Colts QB Philip Rivers, forcing a fumble that results in a 15-yard loss in the team's Week 16 matchup.

San Francisco 49ers RB Christian McCaffrey catches a 9-yard touchdown pass from QB Brock Purdy, marking his second TD of the night.

San Francisco 49ers RB Christian McCaffrey raced out of the backfield for a 24-yard gain, marking his longest carry of the 2025 season.

San Francisco QB Brock Purdy throws his fourth touchdown of the night to WR Jauan Jennings.

San Francisco 49ers QB Brock Purdy delivered a precise 21-yard pass to WR Jauan Jennings as the 49ers move the ball downfield against Indianapolis.

San Francisco 49ers QB Brock Purdy completed a 23-yard pass to WR Skyy Moore in the team's Week 16 matchup.

San Francisco DT C.J. West bursts through the line to sack Colts QB Philip Rivers for an 8-yard loss.

San Francisco 49ers TE George Kittle secured an 11-yard touchdown reception from QB Brock Purdy, giving the 49ers momentum against Indianapolis.

San Francisco 49ers RB Christian McCaffrey flashed his quickness on an 18-yard rush as the 49ers move the chains.

San Francisco 49ers RB Christian McCaffrey catches a 2-yard touchdown pass from QB Brock Purdy in the team's Week 16 matchup against the Indianapolis Colts.

San Francisco 49ers TE Jake Tonges recovered a fumble after Indianapolis Colts RB Ameer Abdullah lost control, giving the 49ers a key takeaway.

San Francisco 49ers QB Brock Purdy connected with WR Demarcus Robinson on a 22-yard touchdown in the team's Week 16  matchup against the Indianapolis Colts.

El Monday Night Football ha llegado y los San Francisco 49ers están listos para enfrentarse de visita a los Indianapolis Colts. Jesús Zárate y Carlos Yustis nos comparten las claves para este partido.

San Francisco 49ers QB Brock Purdy surprised families with incredible holiday gifts, including Toyota vehicles, Rivalries jerseys, and tickets to an upcoming 49ers game, creating unforgettable moments for all, presented by Toyota.

Flag football is taking shape in U.A.E. schools, helping students develop skills, teamwork, and confidence on the field.

Jesús Zárate nos comparte el estado del roster después de los entrenamientos de la Semana 16 en preparación del partido en lunes por la noche en contra de los Indianapolis Colts.

San Francisco 49ers head coach Kyle Shanahan addressed WR Ricky Pearsall's status and shared the latest injury updates as the team prepares for Monday's matchup against the Indianapolis Colts.

El partido de la Semana 16 será en Lunes por la Noche cuando los San Francisco 49ers visiten a los Indianapolis Colts, y Miguel Pasquel tiene las claves para salir con la victoria en este encuentro.