- The 49ers improved to 8-8 overall against the Los Angeles Chargers, including a 4-3 mark at home.
- San Francisco defeated the Chargers for the first time since 2000 (W, 45-17 at San Diego).
- The 49ers have won back-to-back games for the first time this season.
- The 49ers are now 3-1 at home in 2022.
- Kyle Shanahan improves to 1-1 against the Chargers as the head coach of the 49ers.
- The 49ers offense finished with 41 rushing attempts for 157 yards and two touchdowns on the night. San Francisco improved to 8-0 in the regular season, and 2-0 in 2022, when registering 40-or-more rushing attempts in a single game under Shanahan.
49ers Games with 40-or-More Rushing Attempts, 2017-2022
|Date||Opponent||Rushing Attempts||Rushing Yards||Result|
|9/15/19||at Cincinnati Bengals||42||259||W, 41-17|
|9/22/19||vs. Pittsburg Steelers||40||168||W, 24-20|
|10/7/19||vs. Cleveland Browns||40||275||W, 31-3|
|10/13/19||at Los Angeles Rams||41||99||W, 20-7|
|11/15/21||vs. Los Angeles Rams||44||156||W, 31-10|
|11/21/21||at Jacksonville Jaguars||42||171||W, 30-10|
|9/18/22||vs. Seattle Seahawks||45||189||W, 27-7|
|11/13/22||vs. Los Angeles Chargers||41||157||W, 22-16|
- Quarterback Jimmy Garoppolo completed 19-of-28 attempts for 240 yards to go along with five carries for three yards and one touchdown.
- The rushing touchdown marked Garoppolo's second of the season and seventh of his career.
- Running back Christian McCaffrey registered 14 carries for 38 yards and one touchdown to go along with four receptions for 39 yards.
- McCaffrey has registered one-or-more rushing touchdowns in back-to-back games for the 12th time in his career and the first time since Weeks 1-2 of the 2020 season.
- Wide receiver Deebo Samuel tallied two receptions for 24 yards to go along with four carries for 27 yards.
- With two receptions, Samuel has now registered 201 career receptions. In just 46 career games, he has registered 200 career receptions in the third-fewest amount of games by a member of the 49ers dating back to 1970 (tight end George Kittle – 43 games and wide receiver Jerry Rice – 44 games).
Fastest Member of the 49ers to 200 Receptions Since 1970
|TE George Kittle||43|
|WR Jerry Rice||44|
|WR Deebo Samuel||46|
|WR Michael Crabtree||48|
|WR Dwight Clark||50|
- With 24 yards, Samuel has now registered 3,009 career receiving yards. In just 46 career games, he has registered 3,000 career receiving yards in the third-fewest amount of games by a member of the 49ers dating back to 1970 (wide receiver Jerry Rice – 38 games and wide receiver Vic Washington – 44 games).
Fastest Member of the 49ers to 3,000 Receiving Yards Since 1970
|WR Jerry Rice||38|
|WR Vic Washington||44|
|WR Deebo Samuel||46|
|TE George Kittle||47|
|WR Dwight Clark||55|
|WR Michael Crabtree||55|
- Safety Talanoa Hufanga finished with two tackles and an interception of Chargers quarterback Justin Herbert. He now has four interceptions on the season and his career.
- Hufanga's four interceptions this season are the most by a member of the 49ers in a single season since cornerback Perrish Cox registered five interceptions in 2014.
- Defensive lineman Nick Bosa brought down Herbert for a one-yard sack, giving him 9.5 on the season and 34.0 in his career.
- Bosa has now registered 1.0-or-more sacks in seven of his eight games played this season.
- Defensive lineman Charles Omenihu brought down Herbert for a seven-yard sack and a forced fumble. The sack marked his fourth of the season and 11th of his career, and the forced fumble marked the third of his career and first since 2019 as a member of the Houston Texans. It also marked Omenihu's third-career game with 1.0-or-more sacks and one-or-more forced fumbles.
- Defensive lineman Jordan Willis registered four tackles and 1.0 sack of Chargers quarterback Chase Daniel. The sack was Willis' first of the season and gave him 9.5 in his career.