San Francisco 49ers

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San Francisco 49ers 11-4

Indianapolis Colts 8-7

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Brock Purdy Throws Career-High 5 TDs, McCaffrey Breaks 1,000 Yards; Stats and Facts from #SFvsIND

Take a look at key stats from the San Francisco 49ers Week 16 matchup vs. the Indianapolis Colts.

49ers Celebrate Postgame Following 48-27 Win Over Colts🎊

View postgame photos following the San Francisco 49ers Week 16 matchup vs. the Indianapolis Colts.

Lucas Oil Stadium Shakes as the Faithful Show Up

View photos of 49ers fans during the team's Week 16 game against the Indianapolis Colts.

Go Inside the 49ers Locker Room Following Week 16 vs. Colts

Get an inside view of the 49ers locker room following the team's Week 16 win over the Colts presented by Ticketmaster.

49ers Players on Team's Mindset: 'Just Handle Business Each Week'

San Francisco 49ers QB Brock Purdy, TE George Kittle, RB Christian McCaffrey, T Trent Williams, and LB Dee Winters highlighted team chemistry, preparation, and the importance of staying focused as the 49ers look ahead to the playoffs.

C.J. West Talks First-Career Sack, Recaps Win vs. Indianapolis Colts

San Francisco 49ers DL C.J. West reflected on his first-career sack and shared his reaction to the 49ers "Monday Night Football" win over the Indianapolis Colts, presented by Lexus.

49ers Light Up 'MNF' Win vs. Colts; 5 Takeaways from #SFvsIND

The San Francisco 49ers finished their Week 16 "Monday Night Football" contest with a 48-27 win over the Indianapolis Colts at Lucas Oil Stadium.

George Kittle's Best Plays from 115-Yard Game vs. Colts | Week 16

San Fransisco TE George Kittle marked seven receptions for 115 yards and a TD vs. the Indianapolis Colts on "Monday Night Football."

Brock Purdy's Best Plays from 5-TD Game vs. Colts | Week 16

San Francisco 49ers QB Brock Purdy threw a career-high five touchdown passes in his team's Week 16 win over the Indianapolis Colts.

Christian McCaffrey's Best Plays from 146-Yard Game vs. Colts | Week 16

San Francisco 49ers RB Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns Monday Night vs. the Indianapolis Colts.

San Francisco 49ers Top Plays vs. Colts | Week 16

Watch the best plays by the San Francisco 49ers against the Indianapolis Colts in Week 16 of the 2025 NFL season.

Shanahan: 'Proud of How the Team Played All Year'

San Francisco 49ers head coach Kyle Shanahan reflected on the 49ers journey this season, emphasizing consistency, leadership, and the players' ability to overcome injuries and adversity to secure a crucial win.

San Francisco 49ers vs. Indianapolis Colts Game Highlights

View game photos from the San Francisco 49ers Week 16 matchup vs. the Indianapolis Colts at Lucas Oil Stadium.

Collins Brings Down Rivers, Causes Fumble for 15-Yard Loss

San Francisco DL Alfred Collins sacks Colts QB Philip Rivers, forcing a fumble that results in a 15-yard loss in the team's Week 16 matchup.

Christian McCaffrey Adds Second TD to 49ers 'MNF' Lead

San Francisco 49ers RB Christian McCaffrey catches a 9-yard touchdown pass from QB Brock Purdy, marking his second TD of the night.

McCaffrey's 24-Yard Run Marks His Longest Carry of 2025

San Francisco 49ers RB Christian McCaffrey raced out of the backfield for a 24-yard gain, marking his longest carry of the 2025 season.

Brock Purdy's Fourth TD Pass of Night Goes to Jennings

San Francisco QB Brock Purdy throws his fourth touchdown of the night to WR Jauan Jennings.

Brock Purdy Threads 21-Yard Pass to Jennings vs. Colts

San Francisco 49ers QB Brock Purdy delivered a precise 21-yard pass to WR Jauan Jennings as the 49ers move the ball downfield against Indianapolis.

Brock Purdy Finds Skyy Moore for 23-Yard Gain vs. Colts

San Francisco 49ers QB Brock Purdy completed a 23-yard pass to WR Skyy Moore in the team's Week 16 matchup.

C.J. West Brings Down Rivers, Notches First-Career Sack

San Francisco DT C.J. West bursts through the line to sack Colts QB Philip Rivers for an 8-yard loss.

Kittle Hauls in Purdy's Third Touchdown

San Francisco 49ers TE George Kittle secured an 11-yard touchdown reception from QB Brock Purdy, giving the 49ers momentum against Indianapolis.

McCaffrey Dazzles With Stutter Step on 18-Yard Gain

San Francisco 49ers RB Christian McCaffrey flashed his quickness on an 18-yard rush as the 49ers move the chains.

McCaffrey's 15th TD of 2025 Puts 49ers Ahead of Colts

San Francisco 49ers RB Christian McCaffrey catches a 2-yard touchdown pass from QB Brock Purdy in the team's Week 16 matchup against the Indianapolis Colts.

Abdullah Fumbles, Tonges Comes Up With Recovery

San Francisco 49ers TE Jake Tonges recovered a fumble after Indianapolis Colts RB Ameer Abdullah lost control, giving the 49ers a key takeaway.

Purdy Airs It Out for 22-Yard TD to Robinson

San Francisco 49ers QB Brock Purdy connected with WR Demarcus Robinson on a 22-yard touchdown in the team's Week 16 matchup against the Indianapolis Colts.