| 2022-09-01 | Brick by Brick: The Stage is Set |
| 2022-09-01 | John Lynch, Adam Peters Discuss the 53-Man Roster |
| 2022-09-01 | Lance, Garoppolo Discuss Camaraderie in Quarterback Group |
| 2022-09-05 | NFL Throwback: 49ers Top 10 Plays of All Time |
| 2022-09-07 | Los 49ers: Rumbo a Chicago Para el Arranque de la Temporada Regular |
| 2022-09-07 | El Sueño Dorado: Jesús Zárate |
| 2022-09-08 | San Francisco 49ers vs. Chicago Bears Week 1 Preview |
| 2022-09-08 | Shanahan Announces 2022 Team Captains Ahead of Week 1 Matchup |
| 2022-09-08 | Trey Lance ‘Excited to Game Plan’ for Week 1 vs. Bears |
| 2022-09-08 | Fred Warner, Kyle Juszczyk on ‘Setting the Tone’ |
| 2022-09-09 | Williams, Gould on Their Mindset Starting the 2022 Regular Season |
| 2022-09-09 | DeMeco Ryans, Chris Foerster Talk Importance of Fundamentals in Week 1 |
| 2022-09-09 | Al-Shaair, Flannigan-Fowles Share Advice on Workout Meals, Getting Friend-Zoned and Other Q’s Submitted by Fans |
| 2022-09-09 | Kyle Shanahan Talks Excitement for First Game of the Regular Season |
| 2022-09-11 | Todo Listo Para el Partido de Semana 1 Contra los Chicago Bears |
| 2022-09-11 | 3 Puntos Claves: San Francisco 49ers vs. Chicago Bears |
| 2022-09-11 | Samson Ebukam Takes Down Justin Fields for 10-Yard Sack |
| 2022-09-11 | Trey Lance Pinpoints Wide-Open Brandon Aiyuk for 31-Yard Gain |
| 2022-09-11 | Talanoa Hufanga Picks Off Justin Fields for First-Career Interception |
| 2022-09-11 | Talanoa Hufanga con la Primera Intercepción de su Carrera |
| 2022-09-11 | Deebo Samuel con su Primera Anotación de la Temporada |
| 2022-09-11 | Deebo Samuel Rushes for a 6-Yard Touchdown vs. Chicago Bears |
| 2022-09-11 | Deebo Samuel Breaks Off 27-Yard Run Up the Middle |
| 2022-09-11 | Trey Lance Launches 44-Yard Pass to Jauan Jennings |
| 2022-09-11 | Kyle Shanahan Says 49ers ‘Have to Play Better’ Following Week 1 Loss |
| 2022-09-11 | Lance, Bosa, Samuel, Williams Discuss Rebounding in Week 2 |
| 2022-09-11 | Hufanga, Juszczyk, McGlinchey, Burford Recap Week 1 in Chicago |
| 2022-09-11 | San Francisco 49ers Top Plays vs. the Chicago Bears in Week 1 |
| 2022-09-13 | Jugadas Doradas: Momentos Destacados de Samuel, Bosa y Otros en la Semana 1 |
| 2022-09-14 | Shanahan Details the 49ers ‘Physical’ Playing Style |
| 2022-09-14 | Scoreboard Video |
| 2022-09-14 | Lance on the Team Being ‘Locked In’ for Week 2 vs. Seahawks |
| 2022-09-14 | Los 49ers: Esperando la Visita de Seattle Para el Primer Partido en Casa |
| 2022-09-14 | Wilson Jr., Al-Shaair, Brendel, Armstead on Preparing For Seattle |
| 2022-09-15 | NFL Throwback: 49ers Top 10 Plays vs. Seahawks |
| 2022-09-15 | Seattle Seahawks vs. San Francisco 49ers Week 2 Preview |
| 2022-09-15 | 3 Puntos Claves: Seattle Seahawks vs. San Francisco 49ers |
| 2022-09-15 | DeMeco Ryans, Chris Foerster Talk Playing ‘Smarter’ in Week 2 |
| 2022-09-15 | McGlinchey, Jennings, Williams, Warner: 'It's Going to be a Fun Matchup' |
| 2022-09-16 | Gould, Pepper Share Fashion Tips, Wedding Advice and Other Q’s Submitted by Fans |
| 2022-09-16 | Kyle Shanahan Talks Team Energy When Playing at Home |
| 2022-09-17 | Cart Talk: Charvarius Ward 'Excited to Get First Win as a Niner' on Sunday |
| 2022-09-18 | Deebo Samuel Rushes for a 51-Yard Gain vs. the Seattle Seahawks |
| 2022-09-18 | Corrida de Deebo Samuel de 51 Yardas Contra los Seahawks |
| 2022-09-18 | Ross Dwelley Catches for a 38-Yard TD Pass from Jimmy Garoppolo |
| 2022-09-18 | Ross Dwelley Atrapa un Pase de TD de 38 Yardas de Jimmy Garoppolo |
| 2022-09-18 | Tashaun Gipson Sr. Returns Interception 14 Yards vs. Seahawks |
| 2022-09-18 | Jimmy Garoppolo Pinpoints Ray-Ray McCloud III for a 16-Yard Gain |
| 2022-09-18 | Kyle Juszczyk Plows into the End Zone for a Touchdown |
| 2022-09-18 | Charvarius Ward Thwarts Seahawks Trick Play with Goal-Line INT |
| 2022-09-18 | Kyle Juszczyk Corre Sobre la Línea Defensiva Para un TD |
| 2022-09-18 | Nick Bosa Engulfs Geno Smith for a Sack on First Play of the Second Half |
| 2022-09-18 | Jimmy Garoppolo Puts Up 6 on a Quarterback Sneak |
| 2022-09-19 | Shanahan Evaluates 49ers Week 2 Victory vs. Seahawks |
| 2022-09-19 | Banks, Armstead, Jennings, McGlinchey, Aiyuk: 'We Got Each Other's Back' |
| 2022-09-19 | 49ers Top Plays from Week 2 Win vs. Seahawks |
| 2022-09-19 | 49ers Locker Room Praying for Trey Lance Following Week 2 Injury |
| 2022-09-19 | Garoppolo, Juszczyk, Warner, Samuel, Bosa Talk Players Stepping Up |
| 2022-09-20 | The 49ers and the Honor Group Host the 2022 NorCal Honor Bowl |
| 2022-09-20 | Baldy’s Breakdowns: How the 49ers Moved the Chains in Week 2 |
| 2022-09-20 | Jugadas Doradas: Lo Más Notable de Samuel, Hufanga y Otros Ante los Seahawks |
| 2022-09-20 | Tacos de Asada, Birria, ¿Puedes Adivinar el Platillo Latino Favorito de los 49ers? |
| 2022-09-21 | Mic'd Up: Fred Warner is 'Relentless' in 49ers Week 2 Win vs. Seahawks |
| 2022-09-21 | 49 Hours: Battling for the Brotherhood |
| 2022-09-21 | Los 49ers: Inicia el Mes de la Herencia Latina con Alfredo Gutierrez |
| 2022-09-22 | Al-Shaair, Purdy, McGlinchey, Juszczyk: Team is ‘Excited’ to Play in ‘SNF’ |
| 2022-09-22 | Kyle Shanahan Outlines How New Players will Contribute to 49ers Offense |
| 2022-09-22 | San Francisco 49ers vs. Denver Broncos Week 3 Preview |
| 2022-09-22 | Yahoo! Sports Fantasy Football Rundown: 49ers vs. Broncos |
| 2022-09-22 | 3 Puntos Claves: San Francisco 49ers vs. Denver Broncos |
| 2022-09-23 | Dwelley, Woerner Discuss NFL Journeys, Dating Etiquette and More Fan Q's |
| 2022-09-23 | Ryans, Foerster on Young Players Being ‘Put to the Test’ |
| 2022-09-23 | Jimmy Garoppolo Talks Stepping Back Into QB1 Role |
| 2022-09-23 | Kittle: ‘Feels Great to be Back on the Football Field’ |
| 2022-09-23 | Kyle Shanahan on George Kittle: ‘He’s Good to Go’ |
| 2022-09-24 | Kittle, Bosa Talk 'Good Energy' Leading up to Primetime Matchup vs. Broncos |
| 2022-09-26 | En Vivo Desde Denver para el Arranque de los 49ers Contra Broncos |
| 2022-09-26 | Jeff Wilson Jr.'s 37-Yard Run Moves the 49ers into the Red Zone |
| 2022-09-26 | Brandon Aiyuk Abre el Marcador Después de un Pase de Garoppolo |
| 2022-09-26 | 'El Jefe' Jeff Wilson Jr. Mueve las Cadenas con una Corrida de 37 Yardas |
| 2022-09-26 | Jimmy Garoppolo Connects with Brandon Aiyuk for a Touchdown |
| 2022-09-26 | Kerry Hyder Jr. Takes Down Russell Wilson on 'Sunday Night Football' |
| 2022-09-26 | Garoppolo Exploits Samuel's Mismatch for a 32-Yard Sideline Connection |
| 2022-09-26 | ¡Sack del Novato Drake Jackson! |
| 2022-09-26 | Robbie Gould Puts Three on the Board with a 51-Yard Field Goal |
| 2022-09-26 | 49ers Top Plays vs. the Broncos on 'Sunday Night Football' |
| 2022-09-26 | Kyle Shanahan Talks Injuries to Key Players Following ‘SNF’ Loss |
| 2022-09-26 | Garoppolo, Warner, Kittle, Bosa: ‘We’ve Still Got a lot of Football Left’ |
| 2022-09-26 | 49ers Host a Watch Party in San Francisco to Kick off the 2022 Season |
| 2022-09-27 | Alfredo Gutierrez, Memo Ochoa y Andrés Guardado Intercambian Jerseys |
| 2022-09-27 | 49ers Players Take a Trip to RYSE Youth Community Center |
| 2022-09-27 | Jugadas Doradas: Drake Jackson Contribuye al Nivel Alto de Juego Defensivo |
| 2022-09-28 | Los 49ers: Entrando a la Semana 4 con la Tercera Mejor Defensa de la NFL |
| 2022-09-28 | NFL Way To Play Recipient for Week 3: S Talanoa Hufanga |
| 2022-09-29 | Palabra del Día: How Well do 49ers Players Know Their Spanish? |
| 2022-09-29 | Los Angeles Rams vs. San Francisco 49ers Week 4 Preview |
| 2022-09-30 | Schneider Congratulates Wishnowsky on NFC Player of the Month Honors |
| 2022-09-30 | Kyle Shanahan Provides Injury Updates Ahead of ‘MNF’ |
| 2022-09-30 | The 2022 Season Starts Now |
| 2022-09-30 | CiscoKid y Kenna Fueron Invitados Especiales en el Juego Anterior en Casa |
