We've known for some time who the San Francisco 49ers home and road opponents would be. Now that we know the exact order of the 2016 regular season schedule, let's dive into some notes about each matchup.
Week 1 – Monday, Sept. 12 vs. Los Angeles – 7:20 p.m. PT on ESPN
- The 49ers are 20-12-1 in regular season openers at home.
- The Niners begin the season on Monday Night Football for the second consecutive season, after defeating the Minnesota Vikings, 20-3, in Week 1 of 2015.
- San Francisco has won four consecutive Monday Night Football games against division opponents and four consecutive home games on MNF.
- The Niners lead the all-time home series against the Rams, 33-32-2.
- The team's split the season series in 2015, with each team winning in their home stadium.
Week 2 – Sunday, Sept. 18 at Carolina – 10:00 a.m. PT on FOX
- The 49ers are 8-11 in the all-time series vs. Carolina and 3-6 on the road.
- This marks the first contest for San Francisco in Carolina since defeating the Panthers, 23-10, in the 2013 NFC Divisional Round.
Week 3 – Sunday, Sept. 25 at Seattle – 1:05 p.m. PT on FOX
- The 49ers are 7-12 overall on the road at Seattle.
- San Francisco is looking to win at Seattle for the first time since 2011.
Week 4 – Sunday, Oct. 2 vs. Dallas – 1:25 p.m. PT on FOX
- The 49ers are 17-16-1 overall vs. Dallas, including 9-8 at home.
- It is the first time the 49ers have hosted the Cowboys since Sept. 18, 2011.
- San Francisco won the last meeting between the two clubs, 28-17, to open the 2014 season in Dallas.
Week 5 – Thursday, Oct. 6 vs. Arizona – 5:25 p.m. PT on CBS/NFLN/Twitter
- The 49ers are 17-9 at home vs. the Cardinals, and have won six out of the last seven home games vs. Arizona.
- This marks the first time the teams will square off on Thursday Night Football.
Week 6 – Sunday, Oct. 16 at Buffalo – 10:00 a.m. PT on FOX
- San Francisco is 6-5 vs. Buffalo, including a 2-2 record on the road. The Niners have won three of the past four meetings.
- The 49ers make their first trip to Buffalo since Nov. 30, 2008, when they defeated the Bills, 10-3.
Week 7 – Sunday, Oct. 23 vs. Tampa Bay – 1:05 p.m. PT on FOX
- San Francisco leads the overall series record vs. Tampa Bay, 17-5 and are 12-2 at home in the series.
- The two teams will meet for the first time since Dec. 15, 2013, when the 49ers defeated the Buccaneers, 33-14.
- The Buccaneers last visit to San Francisco was a 48-3 victory for the 49ers in 2011.
Week 8 – Sunday, Oct. 30 – BYE
- This marks the second time in the past three seasons that the 49ers have had their BYE in Week 8.
Check out the matchup graphics with details about each of the 49ers 16 regular season games.
Week 9 – Sunday, Nov. 6 vs. New Orleans – 1:05 p.m. PT on FOX
- San Francisco is 48-25-2 all-time vs. New Orleans and 23-11-2 at home.
- The 49ers will host the Saints for the first time since meeting in the 2011 NFC Divisional Round when they defeated the Saints, 36-32.
- The Niners have won three of the past four overall meetings against the Saints and will face off for the fourth time in the past five regular seasons.
Week 10 – Sunday, Nov. 13 at Arizona – 1:25 p.m. PT on FOX
- San Francisco owns the overall series record vs. Arizona, 29-20, including a 12-11 advantage on the road.
- The 49ers are 6-4 over the last 10 overall meetings between the two clubs.
Week 11 – Sunday, Nov. 20 vs. New England – 1:25 p.m. PT on CBS
- The Niners lead the overall series vs. New England, 8-4, and are 4-1 at home against the Patriots.
- This marks the first meeting between the two clubs since the 49ers defeated the Patriots, 41-34, on Dec. 16, 2012 at Gillette Stadium.
- San Francisco will host New England for the first time since Oct. 5, 2008.
Week 12 – Sunday, Nov. 27 at Miami – 10:00 a.m. PT on FOX
- The 49ers and Dolphins are tied at 6 wins apiece in the overall series.
- San Francisco is 2-3 on the road all-time vs. Miami and 1-1 at Sun Life Stadium against the Dolphins.
- This marks only the third visit to Miami for the 49ers since 1995.
Week 13 – Sunday, Dec. 4 at Chicago – 10:00 a.m. PT on FOX
- San Francisco's overall record vs. Chicago is 33-30-1 and 10-17-1 on the road.
- This is the fourth meeting between the teams in the past five years, and the 49ers second consecutive regular season trip to the Windy City.
- The two teams met at Soldier Field last season when the 49ers earned a 26-20 victory in overtime.
- San Francisco will travel to face the Bears in back-to-back seasons for the first time since they visited Chicago in three straight seasons from 2004-06.
Week 14 – Sunday, Dec. 11 vs. New York Jets – 1:05 p.m. PT on CBS
- The 49ers own the overall series record against the Jets, 10-2, including a 4-1 record at home.
- San Francisco has won each of the past two matchups between the two clubs, including a 34-0 win on Sept. 30, 2012 in New York.
- The Niners have won three consecutive home games vs. the Jets, with their last loss coming in 1983.
Week 15 – Sunday, Dec. 18 at Atlanta – 1:05 p.m. PT on FOX
- San Francisco owns the overall series record vs. Atlanta, 47-30-1, and is 19-19-1 on the road.
- The two teams met at Levi's Stadium last season when the 49ers won 17-16.
- The 49ers will enter the matchup with a 6-8 overall record in the Georgia Dome, including a victory in the NFC Championship Game, 28-24, on Jan. 20, 2013.
Week 16 – Saturday, Dec. 24 at Los Angeles – 1:25 p.m. PT on FOX
- The 49ers are 66-64-3 in the overall series against the Rams.
- San Francisco will face the Rams in Los Angeles at the Los Angeles Memorial Coliseum for the first time since Sept. 16, 1979, a 27-24 defeat.
- The Niners hold a slight edge as the road team in the series with a 33-32-1 all-time record.
- This marks the 49ers first game at the Los Angeles Memorial Coliseum since facing the L.A. Raiders on Sept. 29, 1991.
Week 17 – Sunday, Jan. 1, 2017 vs. Seattle – 1:25 p.m. PT on FOX
- San Francisco is 15-20 in the all-time series vs. Seattle and 8-8 at home.
- The Niners have won five out of the last seven home games against the Seahawks.