The San Francisco 49ers will look to snap a three-game losing streak when they head to New York to battle the Giants on "Sunday Night Football."
San Francisco won in the Meadowlands last year by intercepting Eli Manning five times. The 49ers are 0-2 on the road so far this season, with losses in Pittsburgh and Arizona.
The Giants have won two straight after dropping their first two games of the year.
Here are the experts' picks from around the web for the Week5 clash. Give us your predictions in the comment section below...
Pete Prisco of CBS Sports: Giants 31, 49ers 21
"The 49ers are really struggling on offense and face a long trip East. That's never easy. Colin Kaepernick is really having issues. The Giants seemed to right things last week against the Bills. That will carry over. Eli Manning plays well."
Pete Schrager of Fox Sports: 49ers 20, Giants 17
"When you sign a contract north of $40 million, you expect to be part of the game plan. So you can imagine Torrey Smith, he of just two receptions last week, appears frustrated with the 49ers offense. "We have to get it together as a unit," Smith said on Sunday after a dreadful 17-3 loss to the Packers. "It's not always the offensive line's fault. It's not always Kap. We have to all be in sync on these plays to make it happen." The season is slipping away for San Francisco. Before I jump ship, I'll give the Niners one more game where they dig deep and find a way. I just don't believe this team is as bad as it has played the last three weeks."
Gerry Dulac of the Pittsburgh Post-Gazette:](http://www.post-gazette.com/sports/dulacs-picks/2015/10/08/Gerry-Dulac-s-NFL-Picks-Week-5/stories/201510080152)** Giants 23, 49ers 17
"The 49ers have lost three in a row and have scored just 28 points in those three games. They have managed just five touchdowns, fewest in the league. They'll need to improve that total against a Giants defense that ranks last in pass defense."
Greg Cote of the Miami Herald: Giants 19, 49ers 17
"Not sure if Colin Kaepernick and Frans' sputtering offense are worthy of prime time, but a shoutout to Eli Manning, whose 171 consecutive starts are most of any current NFL player at any position. Manning is 5-2 in his career vs. SF, which has dropped four in a row on the road. Hunching it's closer than the betting number, though."
NFL.com's panel of five experts: four pick Giants, one picks 49ers
ESPN.com's panel of 13 experts: 13 pick Giants