The San Francisco 49ers begin divisional play with a Week 3 road matchup against the unbeaten Arizona Cardinals.
San Francisco has won 10 out of the last 12 meetings, including the most recent in Week 17 of last season when the 49ers won at home, 20-17.
The 49ers will be looking to bounce back from their first loss of the year, a 43-18 defeat at the hands of the Pittsburgh Steelers.
Here are the experts' picks from around the web for the Week 3 clash. Give us your predictions in the comment section below...
Pete Prisco of CBS Sports: Cardinals 27, 49ers 17
"The 49ers will be playing consecutive road games in this one. That is always tough, even on a short trip. The Cardinals are 2-0 and have played well on both sides of the ball."
Mike Florio of Pro Football Talk: Cardinals 34, 49ers 24
San Francisco and Arizona have faced off 51 times. Here are the best shots from the teams' meetings.
"The Cardinals look to be every bit as good as they were a year ago, without all the injuries. The 49ers aren't as bad as feared, but they're likely not good enough to steal a win in Arizona."
Pete Schrager of Fox Sports: Cardinals 24, 49ers 17
"Arizona rookie David Johnson is the odds-on early favorite for Offensive Rookie of the Year, and rightfully so. He is the first player in NFL history to score receiving, rushing and kickoff return touchdowns in his first two career games. Cardinals quarterback Carson Palmer has been even better. Bruce Arians' team doesn't lose much at home. Can't pick against them."
Elliot Harrison of NFL.com: Cardinals 21, 49ers 13
"The Cards move to 3-0 behind another strong performance from QB Carson Palmer. Palmer has been lights out, especially when it's been needed. His passer rating in the fourth quarter is 152.1, tops in the league. San Francisco back Pierre Garçon must be more involved than he was in Week 2 (13 carries for 43 yards). Otherwise, the Niners will be forced to convert on third downs -- and Arizona is allowing only a 30 percent conversion rate on third downs. Good luck."
SB Nation's panel of eight experts: seven pick Cardinals, one picks 49ers
ESPN's panel of 13 experts: 12 pick Cardinals, one picks 49ers
USA TODAY's panel of seven experts: seven pick Cardinals