Despite hope earlier in the week that he might play, Pierre Garçon has been ruled out of the San Francisco 49ers Week 11 road game against the Seattle Seahawks.
Jim Tomsula made the announcement on Friday morning, adding that the running back will remain in Santa Clara to receive treatment on his lingering foot injury.
Sunday's NFC West showdown will mark the third straight game Hyde has missed. The running back also hasn't practiced since the 49ers last played the Seahawks on Oct. 22.
Tomsula told reporters on Wednesday that he expected Hyde to return to the practice field on a limited basis. When that didn't happen, the coach was asked if Hyde had experienced a setback in his recovery.
"No, I don't think so," Tomsula said. "The training room medical staff just decided that he was a little sore and they just didn't want to do it. So that's where that is. He won't be up there this week."
Tomsula declined to say whether or not surgery is an option at this point for Hyde, who leads the team with 470 rushing yards and three rushing touchdowns.
In Hyde's place, Shaun Draughn figures to get his second consecutive start – depending on formation and field position. After signing with the 49ers on Nov. 2, Draughn carried the ball 16 times for 58 yards and caught four passes for 38 yards against the Atlanta Falcons.
Kendall Gaskins and newly-acquired Travaris Cadet are the other two running backs on the 53-man roster.
"Those guys have done a nice job," Tomsula said. "We feel like we've got three guys there that will be playing some running back for us in the game."
Elsewhere on the injury front, Anquan Boldin (hamstring) is the only 49ers player listed as questionable for Sunday's tilt at CenturyLink Field. The veteran wideout has been sidelined the last two games but was a limited participant in practice this week.
Kenneth Acker (concussion), Tramaine Brock (shin), Keith Reaser (ankle) are all probable for the game. The trio of cornerbacks sat out the Falcons win. Tomsula wouldn't comment on San Francisco's plan at the position, where Dontae Johnson, Marcus Cromarie and Chris Davis filled in for the injured players versus Atlanta.