San Francisco and Buffalo have faced off in 11 regular season games. The 49ers have won six of the 11 games.
*The San Francisco 49ers take on the Buffalo Bills in Week 6 of the 2016 regular season. The matchup takes place on Sunday October 16 at 10:00 a.m. PT.
Here are all the ways you can watch the action.*
Watch on TV
The game will be broadcast on FOX in the areas in RED below.
Play-by-Play: Dick Stockton
Color Analyst: David Diehl
Sideline Reporter: Kristina Pink*
Out of the broadcast area? 49ers fans in the U.S. can also sign up for NFL Game Pass to watch every 49ers regular season game on demand.
Overseas? International NFL Game Pass is available here.
TuneIn:Sign up for 1st & Goal premium station to listen to every 49ers game
Bay Area radio: KGO 810 & KSAN 107.7 The BonePlay-By-Play:Ted Robinson
Color Analyst: Tim Ryan*
Spanish radio: ESPN Deportes and KSSKF 910
Full List of 49ers Radio Affiliates
Videos to Watch before the Game