LOS ANGELES - The. Streak. Is. Over

The San Francisco 49ers captured their second win of the season with a 22-21 victory over the Los Angeles Rams.

San Francisco erased a 14-point fourth quarter deficit and won the game on a last-minute touchdown and two-point conversion. With the "W," the 49ers are now 2-13 on the season while the Rams dropped to 4-11.

Here's what we learned in Week 16.

Kaep's Heroics Lift 49ers

Colin Kaepernick accounted for three touchdowns on the day. The quarterback opened the scoring with a 19-yard touchdown pass to Pierre Garçon and ended the game with two fourth-quarter scores.

Trailing 21-7, Kaepernick took off on a 13-yard touchdown run. After a quick stop by the defense, the quarterback engineered a 10-play, 73-yard drive that culminated in a 10-yard touchdown pass to Rod Streater. Rather than kick the PAT and play for overtime, Chip Kelly opted to roll the dice and go for the win.

The play call was a run-pass option that resulted in Kaepernick scrambling for the end zone. The quarterback skied across the goal line to put San Francisco up 22-21.

Kaepernick ended the game with 257 passing yards and two touchdowns with a passer rating of 98.2. The quarterback added 15 yards rushing in what was his sixth game this season with multiple scores.

Defense Records Two Interceptions, Four Sacks

San Francisco made Jared Goff's life difficult throughout the game. The top pick in this year's draft had been sacked 14 times over his past four games, and the 49ers got to him four more times on Sunday. Ahmad Brooks, DeForest Buckner, Ronald Blair III and Eli Harold accounted for the sacks as Goff was consistently under siege.

The relentless pass-rush played a part in San Francisco's two takeaways as well. Tramaine Brock grabbed his first interception of the season in the first quarter. The pick led to Hyde's touchdown. Then with the Rams trying to get in field-goal range in the game's final seconds, Rashard Robinson intercepted Goff on a pass towards the right sideline. The rookie's first career pick sealed the win for San Francisco.

The 49ers limited Goff to just 90 yards on 11-of-24 passing and a quarterback rating of 35.1.

49ers Lose Hyde to Knee Injury

San Francisco's franchise running back scored the 49ers first touchdown of the day on a 19-yard catch-and-run. Hyde left the game in the beginning of the fourth quarter, however, after taking a vicious hit from Rams cornerback E.J. Gaines. Hyde caught a short pass to the left, and before he could get his head around to turn up field, Gaines dove at his legs to bring him down. The ball-carrier was able to walk to the locker room under his own power but was officially announced as out with a knee injury.

Hyde entered the game just 50 yards shy of his first 1,000-yard season and left the contest with 38 yards on 13 carries. It will be a shame if the injury keeps Hyde out of the season finale against the Seattle Seahawks and away from the personal achievement.

Niner Nuggets

-- John Theus made his first career start on Sunday. The rookie made his debut at right tackle while Trent Brown moved over to left tackle for the first time in his career.

-- Joshua Garnett left the game briefly with a finger injury but returned shotly after. Alex Balducci made his NFL debut, getting a few snaps at right guard when Garnett went down.

-- Streater led the 49ers with six receptions for 63 yards and has now scored in two straight games.

-- Gerald Hodges was back in the lineup against the Rams and recorded a game-high 13 tackles.

-- DeAndre Smelter made his NFL debut but did not catch a pass.