The two franchises have met 65 times since 1950. San Francisco holds the edge with 37 wins.
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A look at notable statistics for the San Francisco 49ers Week 16 road matchup against the Detroit Lions, courtesy of San Francisco's communications staff.
Click on the image to download.
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![W2W4Det-Embed.jpg](https://static.clubs.nfl.com/image/private/t_editorial_landscape_mobile/t_lazy/f_auto/49ers/uvvpmbzlutef2vpopnhd.jpg)
](http://media.49ers.com/articledisplay.cfm?articleid=8403)