49ers vs. Saints Matchup Information

History: 49ers at Saints

  • San Francisco is 49-26-2 all-time vs. New Orleans and 26-14 on the road.
  • The Niners have won three of the past four meetings against the Saints at the Mercedes-Benz Superdome, including a thrilling 48-46 victory in 2019.
  • This marks the first time the 49ers and Saints face off in consecutive regular seasons since 2013-14.

Players and Coaches to Know: