History: 49ers at Saints
- San Francisco is 49-26-2 all-time vs. New Orleans and 26-14 on the road.
- The Niners have won three of the past four meetings against the Saints at the Mercedes-Benz Superdome, including a thrilling 48-46 victory in 2019.
- This marks the first time the 49ers and Saints face off in consecutive regular seasons since 2013-14.
Players and Coaches to Know: