History: 49ers vs. Rams
- San Francisco leads the all-time series against the Rams, 71-67-3.
- The Niners are scheduled to host the Rams in prime time for the second-consecutive season, having defeated the Rams at Levi's® Stadium, 34-31, on Saturday Night Football in Week 16 of 2019.
- The two teams are set to meet on Sunday Night Football for the first time since 2004.
- San Francisco is 6-3-1 in their last 10 meetings at home against the Rams, with the Niners holding a 35-34-2 series record at home against the Rams.
Players and Coaches to Know: