History: 49ers vs. Cardinals
- San Francisco opens the season at home against the Cardinals for the first time since 2008.
- The 49ers are 18-12 at home against the Cardinals and have won seven out of their last 11 home games vs. Arizona.
- Last meeting at Levi's® Stadium: The 49ers pulled off a 36-26 last-minute victory over the Cardinals in Week 11 with a 25-yard touchdown pass from Jimmy Garoppolo to Jeff Wilson Jr. with :31 left in the game.
Players and Coaches to Know:
49ers
- Head Coach: Kyle Shanahan
- Quarterback: Jimmy Garoppolo
- Wide Receiver: Deebo Samuel
- Linebacker: Fred Warner
Cardinals
- Head Coach: Kliff Kingsbury
- Quarterback: Kyler Murray
- Wide Receiver: DeAndre Hopkins
- Linebacker: Chandler Jones
