ST. LOUIS -- The frustration is evident, but so is the resolve. 

The San Francisco 49ers suffered their sixth loss in their last seven games on Sunday, falling 27-6 to the division rival St. Louis Rams.

Afterwards, two of San Francisco's veteran leaders – players who have experienced 13-win seasons and six-win seasons – spoke about the team's temperament at 2-6 and last place in the NFC west.

"It's how you respond to everything negative that happens," NaVorro Bowman said. "When I signed up, I signed up to play through wins and losses.

"This is the type of team we have. There's no genie that's coming through the door who is going to make us better. We have to put the work in, come together as a team and keep moving forward."

Added Joe Staley: "You can only control what you do on the field; what your performance is. That's the mindset we have to have. And that's what we have to be better at. Everyone has to do their job. Nothing more, nothing less."

In Sunday's one-sided defeat, the 49ers were kept out of the end zone for the second consecutive game. Injuries certainly played their part – the team was without Pierre Garçon, Anquan Boldin for the entire game and Reggie Bush, Mike Davis and Garrett Celek for much of the game – but nobody used the attrition as an excuse.

By the end of the afternoon, San Francisco's only healthy running back on the roster was Kendall Gaskins – a player promoted on Saturday from the practice squad who was making his NFL debut.

"I wish I could go ask the coaches if I could play running back, but that's not how this business works," Bowman said. "We have to do our job that we signed up for. I'm sure that the offensive side will get it together soon."

The defense played inspired football for significant chunks of the game. Its downfall, however, was the home-run play. Todd Gurley broke off a 71-yard touchdown, Tavon Austin recorded a 66-yard score on a bubble screen and Jared Cook hauled in a 49-yard reception to set up another touchdown.

"We held them off so much," Bowman said. "It's our job to keep them out of the end zone. We did a good job of that for the most part today. If they don't have those big plays, we still have a shot to win the game."

Bowman admitted feeling demoralized by the outcome. But the season is only at its halfway point and the linebacker told reporters that the team will continue to attack each week no matter the circumstances.

"It's hard to deal with. I'm not going to sit here and act like it's not," Bowman said. "At the end of the day though, there are 16 games on the schedule and you can't run from it. We have to go to work and see if we can get this thing right."