For the second consecutive week, the San Francisco 49ers went to overtime. And for the second consecutive week the 49ers lost in gut-wrenching fashion. Adam Vinatieri's walk-off, 51-yard field goal gave the Indianapolis Colts a 26-23 win in Week 5.

San Francisco is now 0-5 on the season and has lost its last four games by a combined 11 points.

Here are Sunday's top takeaways.

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1.** San Francisco's offense was silent until the fourth quarter, being limited to three field goals through the first 45 minutes. The 49ers finally came to life down 23-9 and under 10 minutes remaining in the game. Pierre Garçon hit Marquise Goodwin on a 51-yard bomb down the middle of the field. That drive was capped by a six-yard touchdown pass to Kyle Juszczyk to cut the Colts lead to 23-16.

Following a stop by the defense, Hoyer and rookie tight end George Kittle were responsible for a game-tying score. Kittle caught five passes on the drive, including a fourth-down reception to keep San Francisco's hopes alive and a 5-yard touchdown catch on 4th-and-goal to tie the game at 23.

The 49ers got one possession in overtime needing just a field goal to win it but were forced to punt.

Hoyer, who had a very up-and-down game, ended up with huge statistical numbers: 29-of-46 passing for 353 yards, two touchdowns, no interceptions and a passer rating of 101.1. That's Hoyer's second-highest yardage output in his career. Goodwin led the 49ers with 116 yards, his first 100-yard game in San Francisco. Pierre Garçon had eight receptions for 94 yards and Kittle finished with seven receptions for 83 yards and one touchdown.

2. Pierre Garçon carried the ball just eight times for 11 yards. he also caught one pass for seven yards. He surrendered a lot of playing time to Matt Breida. The rookie posted 49 yards on 10 carries as Kyle Shanahan opted to feed the hot hand. Breida added three receptions for 22 yards. Hyde was never reported to have an injury. It was merely a personnel decision from Shanahan.

3. The defense came up with a clutch turnover in overtime as Ray-Ray Armstrong picked off Jacoby Brissett at the goal line. As a whole, however, San Francisco struggled to contain the Colts offense. Brissett threw for 314 yards, 177 of which went to T.Y. Hilton. Colts rookie running back Marlon Mack torched the 49ers for 91 yards on just nine carries. Mack scored on a 22-yard touchdown run that capped a four-play, 60-yard drive. Frank Gore ran the ball 14 times for 48 yards and caught three passes for 38 yards. He passed Eric Dickerson for seventh on the NFL's all-time rushing list.

DeForest Buckner and Elvis Dumervil each got a sack. Jaquiski Tartt and Earl Mitchell split a sack as well.

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4.** Robbie Gould continues to be money for the 49ers. Gould went 3-for-3 on his field-goal attempts. His third make, a 40-yarder in the fourth quarter, was Gould's 300th-career field goal. The kicker has now made 31 consecutive attemps dating back to 2015. He's made all 14 of his field goals in 2017 with the 49ers.

5. Penalties continue to haunt San Francisco. The 49ers had double-digit penalties once again on Sunday, being flagged 10 times for 77 yards. San Francisco went just 4-of-14 on third down as well. The 49ers did improve in the red zone, however, scoring on 2-of-3 trips inside the Colts 20-yard line.

6. Ahkello Witherspoon, who made his NFL debut on Sunday, left the game and did not return with a concussion after taking an illegal block in the back. Asa Jackson left the game as well with a hamstring injury. Garrett Celek and Rashard Robinson had various knicks during the game, but they returned to action.