History: 49ers at Cardinals
- San Francisco owns the overall series record vs. Arizona, 31-26.
- Last season, the two teams squared off on Thursday Night Football for the second time in four years, with San Francisco defeating Arizona on the road, 28-25.
- In 2019, the 49ers defeated the Los Angeles Rams at home on Saturday Night Football, 34-31.
Players and Coaches to Know:
49ers
- Head Coach: Kyle Shanahan
- Quarterback: Jimmy Garoppolo
- Running Back: Raheem Mostert
- Cornerback: Richard Sherman
Cardinals
- Head Coach: Kliff Kingsbury
- Quarterback: Kyler Murray
- Running Back: Kenyan Drake
- Cornerback: Patrick Peterson
