Deebo Samuel Bowls Over Defenders to Pick Up 26 Yards

Watch the San Francisco 49ers top plays from their Week 11 win over the Arizona Cardinals in Mexico City.

Watch every catch from San Francisco 49ers tight end George Kittle's two-touchdown game against the Arizona Cardinals in Mexico City.

Watch the best plays from San Francisco 49ers quarterback Jimmy Garoppolo's four-touchdown game against the Arizona Cardinals in Mexico City.

San Francisco 49ers cornerback Samuel Womack III recorded his first-career interception off of Arizona Cardinals quarterback Trace McSorley during the team's Week 11 win in Mexico City.

San Francisco 49ers wide receiver Brandon Aiyuk registered his second touchdown of the game on a pass from quarterback Jimmy Garoppolo.

San Francisco 49ers tight end George Kittle encountered little resistance en route to his second touchdown of 'Monday Night Football'.

San Francisco 49ers defensive lineman Kevin Givens took down Arizona Cardinals quarterback Colt McCoy for a sack.

San Francisco 49ers linebacker Fred Warner took down Arizona Cardinals quarterback Colt McCoy for a sack.

San Francisco 49ers running back Elijah Mitchell moved the sticks on a 19-yard run.

Arizona Cardinals quarterback Colt McCoy couldn't escape San Francisco 49ers defensive lineman Nick Bosa during "Monday Night Football" in Mexico City.

Wide receiver Deebo Samuel ran 39 yards to the end zone for a 49ers touchdown.

San Francisco 49ers quarterback Jimmy Garoppolo connected with tight end George Kittle for a 39-yard touchdown.

San Francisco 49ers defensive back Jimmie Ward intercepted a pass from Arizona quarterback Colt McCoy off of a tip by Cardinals running back James Conner.

San Francisco 49ers quarterback Jimmy Garoppolo pinpointed wide receiver Brandon Aiyuk for a 7-yard touchdown.

San Francisco 49ers quarterback Jimmy Garoppolo connected with wide receiver Deebo Samuel for a first down.

San Francisco 49ers cornerback Samuel Womack III showed off his speed on punt coverage to pin the Arizona Cardinals inside of their own five yard line.

San Francisco 49ers running back Christian McCaffrey broke through the Arizona Cardinals defense for a 20-yard gain.

San Francisco 49ers defensive back Deommodore Lenoir registered a tackle for loss of Arizona Cardinals wide receiver Rondale Moore.

Ahead of the team's Week 11 matchup and return to Mexico, watch highlights from when the San Francisco 49ers faced the Arizona Cardinals in 2005.

Watch some of the San Francisco 49ers best highlights from their Week 10 win vs. the Los Angeles Chargers.

San Francisco 49ers defensive lineman Nick Bosa ran into the Chargers backfield to take down DeAndre Carter for a loss of six yards.

San Francisco 49ers safety Talanoa Hufanga picked off Los Angeles Chargers quarterback Justin Herbert with a game-sealing interception.

San Francisco 49ers running back Christian McCaffrey ran through the Chargers defense to add six points to the scoreboard.

San Francisco 49ers wide receiver Brandon Aiyuk converted a 3rd-and-long after catching a 24-yard pass from quarterback Jimmy Garoppolo.

San Francisco 49ers wide receiver Deebo Samuel picked up 15 yards and a first down.