History: 49ers vs. Bills
- San Francisco is 6-6 vs. Buffalo, including a 4-3 record at home. The Niners have won three of the past five meetings.
- The 49ers are facing the Bills on Monday Night Football for the first time, as San Francisco holds a 49-28 overall record on MNF. The Niners 49 victories on MNF are the most by any NFL franchise.
- The Bills are making their first trip to Levi's® Stadium, with San Francisco hosting Buffalo for the first time since October 7, 2012, when they defeated the Bills, 45-3.
Players and Coaches to Know: