San Francisco 49ers at Arizona Cardinals
History: 49ers at Cardinals
- San Francisco owns the overall series record vs. Arizona, 31-26.
- Last season, the two teams squared off on Thursday Night Football for the second time in four years, with San Francisco defeating Arizona on the road, 28-25.
- In 2019, the 49ers defeated the Los Angeles Rams at home on Saturday Night Football, 34-31.
Players and Coaches to Know: