Isaac Guerendo

Experience: 3 years

Height: 6-0

Age: 25

Weight: 221 lbs

College: Louisville

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YEAR	TEAM	G	FUM	LOST	FF	OWN FR	OPP FR	TD
2025	San Francisco 49ers	14			1
2024	San Francisco 49ers	16	3	1	0
TOTAL		30	3	1	1	0	0	0

YEAR	TEAM	G	Total	Solo	INT	TDS	YDS	AVG	LNG
2025	San Francisco 49ers	14	2	2
2024	San Francisco 49ers	16	0	0
TOTAL		30	2	2	0	0	0	0	0

Biography

Registered the fastest 40-yard dash time among RBs at the 2024 NFL Combine with a 4.33.
Received Indiana's Mr. Football position award in high school as the state's top wide receiver as a senior.
One of just 14 people in the US with the last name Guerendo.

Registered the fastest 40-yard dash time among RBs at the 2024 NFL Combine with a 4.33.
Received Indiana's Mr. Football position award in high school as the state's top wide receiver as a senior.
One of just 14 people in the US with the last name Guerendo.

Appeared in 40 games (1 start) over five seasons at Louisville (2023) and Wisconsin (2018-22) and registered 231 carries for 1,392 yards (6.0 avg.) and 17 TDs. As a redshirt senior in 2023, appeared in 14 games (1 start) at RB and registered 132 carries for 810 yards (6.1 avg.) and 11 TDs. In 2022 at Wisconsin, appeared in 12 games and tallied 64 carries for 385 yards (6.0 avg.) and 5 TDs, earning Honorable Mention All-Big Ten Special Teams (KR). Appeared in 4 games as a junior in 2021 and posted 23 carries for 160 yards (7.0 avg.) and 1 TD. Played in one game during the shortened 2020 COVID-19 season and registered 11 carries for 36 yards (1.0 avg.). As a redshirt freshman in 2019, appeared in six games

Appeared in 16 games (3 starts) as a rookie and registered 84 carries for 420 yards and 4 TDs on the ground to go along with 15 receptions for 152 yards through the air.
Registered 10 carries for a team and career-high 99 yds at Sea. (10/10). Added a 76-yd. run which marked the team's longest run of the season and the longest run by a 49ers player since former RB Raheem Mostert registered an 80- yd. run at NYJ (9/20/20).
Registered 14 carries for a team-high 85 yds. and 1 TD vs. Dal. (10/27) which marked the first rushing TD of his career.
Registered 4 carries for 19 yds., including a 15-yd. rushing TD at Buf. (12/1).
Registered 15 carries for 78 yds. and 2 TDs vs. Chi. (12/8) which gave him 4 career rushing TDs.
The rushing TDs vs. Chi. (12/8) made him the first 49ers RB to score 2-or-more rushing TDs in their first career start since former RB Carlos Hyde [2 rushing TDs vs. Min. (9/14/15)].
With 1 rushing TD at Buf. (12/1/24) and 2 rushing TDs vs. Chi. (12/8), marked the first time that he registered 1-or-more rushing TDs in consecutive games.
Became the first 49ers rookie RB to register consecutive games with 1-or-more rushing TDs since RB Elijah Mitchell did so in 2021 [1 rushing TD vs. Min. (11/28/21); 1 rushing TD at Sea. (12/5/21)].
With 2 rushing TDs vs. Chi. (12/8), became the first 49ers rookie to register 2-or-more rushing TDs in a game since former RB Michael Robinson [2 rushing TDs vs. Phi. (9/24/06)].
Registered a career-high 16 carries for 57 yards vs. LAR (12/12).

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