ST. LOUIS -- The San Francisco 49ers hit the road for a Week 8 divisional showdown with the rival St. Louis Rams.

San Francisco has won its last three games in the Edward Jones Dome.

Refresh this page throughout the game for the latest happenings as the 49ers try to secure their first NFC West victory of the 2015 season.

Pregame Notes 

Colin Kaepernick will be without his leading rusher and receiver on Sunday. 

The 49ers announced that both Pierre Garçon (foot) and Anquan Boldin (hamstring) are inactive against the Rams. 

Hyde was ruled out on Friday, but the Boldin news comes as somewhat of a surprise. The veteran wide receiver told reporters on Friday that he planned to play.

Sunday will mark the first game Boldin has missed since he joined the 49ers in 2013. 

Through seven games, Boldin leads San Francisco with 31 receptions for 372 yards and two touchdowns. Hyde has totaled 470 yards and three touchdowns.

Reggie Bush will start in place of Hyde, with Mike Davis and Kendall Gaskins also in line to garner touches out of the backfield. Gaskins was elevated from the practice squad to the active roster on Saturday. He will make his NFL debut.

Quinton Patton, Bruce Ellington and Jerome Simpson are the other active wide receivers behind Torrey Smith. Simpson, who served a six-game suspension to start the year, will see his first game action since 2013. He caught 48 passes for 726 yards for the Minnesota Vikings that year. 

The other five inactive players for San Francisco are: WR DeAndrew White, G Brandon Thomas, OL Ian Silberman, NT Mike Purcell and TE Blake Bell. 

St. Louis' are as follows: QB Sean Mannion, S Christian Bryant, RB Trey Watts, TE Justice Cunningham, G Cody Wichmann, DE Chris Long and DT Doug Worthington.

First Quarter

The 49ers began the game on offense and immediately put St. Louis on its heels.

A week after recording just eight first downs in 60 minutes versus the Seattle Seahawks, San Francisco struck with first downs on each of its first two plays from scrimmage. 

Garrett Celek caught a pass for 13 yards before Torrey Smith got into the action with an 11-yard gain to move the 49ers near midfield.

Facing a third down two plays later, Kaepernick scrambled for nine yards to put his team in field-goal range. The drive stalled there, but Phil Dawson connected on a 54-yard attempt to give San Francisco an early lead.

The kick marked the 12th consecutive make for Dawson this season. Also of note on the opening possession was that Jordan Devey got the start at right tackle.

49ers lead 3-0 with 10:34 left in the first quarter after nine-play drive spanning 44 yards.

The San Francisco defense bottled up the Rams on their first two drives, limiting Todd Gurley and Co. to just 22 yards and one first down.

But on St. Louis' second punt of the afternoon, an unfortunate sequence on special teams left the 49ers backed up to their own end zone without their starting running back.

San Francisco committed three penalties on the punt return – two blocks in the back and one unsportsmanlike conduct. Bush, who returned the kick, injured his knee after slipping and falling on the concrete track surrounding the field. The running back stayed down for several minutes before being carted to the locker room. The team initially announced that Bush was questionable to return.

The penalties pushed the 49ers back to the 3-yard line, where Mike Davis carried the ball three straight times. On each occasion, the rookie runner lost ground. The third-down play resulted in a safety.

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49ers lead 3-2 with 4:29 left in the first quarter.**

San Francisco continued to play stingy defense despite St. Louis having good field position. The high effort paid off late in the quarter when Jaquiski Tartt, starting in place of the injured Antoine Bethea, forced a Tavon Austin fumble after the receiver caught a 25-yard pass.

Eli Harold recovered the loose ball and returned it 13 yards. The turnover gave the 49ers their first fumble recovery of the season.

Second Quarter

The teams continued to trade punts until an explosive play from an electric rookie runner broke the stalemate.

On a 1st-and-10 play from the St. Louis 29-yard line, Gurley broke into the 49ers secondary untouched and cruised into the end zone for a 71-yard touchdown. The Rams running back got the carry out of the shotgun formation and burst through a sealed-off hole on the right side of the line.

The Rams converted the ensuing two-point attempt as Nick Foles found Jared Cook in the back of the end zone between two defenders. 

49ers trail 10-3 with 10:25 remaining in the second quarter.

Later in the quarter, a short punt Bradley Pinion set up the Rams in San Francisco territory.

St. Louis recorded a couple of first downs before the 49ers stopped the threat in the end zone to force a 38-yard field goal.

49ers trail 13-3 with 6:56 remaining in the second quarter.

San Francisco special teams ace L.J. McCray exited the game with a knee injury and was initially listed as questionable to return. Garrett Celek also went to the locker room early to be evaluated for a head injury. 

The 49ers responded with a strong offensive possession late in the half.

Kaepernick connected with Vernon Davis on a 3rd-and-7 for 11 yards to extend the drive. On the next play, Kaepernick threaded the needle between three Rams defensive backs to hit a sprawling Patton for 33 yards.

A late hit on a Mike Davis gave San Francisco a 1st-and-goal, but the 49ers were forced to settle for a Dawson 26-yard field goal.

49ers trail 13-6 with 1:56 left in the second quarter after 12-play drive spanning 73 yards.

The Rams did not settle for a six-point lead heading into the break. With 39 seconds remaining in the half, Foles found Cook down the seam for a 49-yard gain. Kenneth Acker and Eric Reid collided trying to make the tackle, leaving the former shaken up on the field.

After a facemask penalty on Ahmad Brooks set the Rams up at the goal line, Austin scored from two yards out on a fly sweep.

49ers trail 20-6 with 0:18 remaining in the second quarter.

San Francisco took a knee on their next play from scrimmage to end the half, which featured a whopping 18 accepted penalties.

The Rams outgained the 49ers, 225-113. Kaepernick completed 12-of-23 passes for 98 yards while the the running game managed just 18 total yards on 15 carries. 

NaVorro Bowman led the way on defense with five tackles.

Third Quarter

The 49ers announced a host of injury updates coming out of the locker room: McCray and Bush were downgraded to out, Celek was diagnosed with a concussion, Mike Davis was out suffered a hand injury and Keith Reaser was questionable with an ankle issue.

The injury to Mike Davis meant that Gaskins was the only remaining healthy running back.

Midway through the quarter, San Francisco appeared cut the 14-point deficit in half when Brooks scooped up a fumble forced by Arik Armstead and returned it for a touchdown.

But referees flagged Brooks for a facemask penalty, negating the score and giving the Rams a fresh set of downs in 49ers territory.

San Francisco did, however, prevent a score as Quinton Dial blocked a field goal attempt to keep his team within striking distance.

Fourth Quarter

Following a quiet third quarter, the Rams put the game out of reach midway through the fourth when Austin took a bubble screen 66 yards for a touchdown.

The back-breaker came on 3rd-and-3 and gave St. Louis a three-score advantage. 

49ers trail 27-6 with 8:34 left in the fourth quarter.

Pinion later sustained a calf injury, forcing Dawson to handle punting duties. The veteran place kicker launched a 48-yard punt. 

San Francisco drove into St. Louis territory with under five minutes remaining but came away empty-handed after a Kaepernick pass on fourth down fell incomplete.

The Rams ran out the remainder of the clock to seal the 27-6 victory. The 49ers are now 2-6 and 0-3 in the NFC West.