"Monday Night Football" is returning to the Bay Area.

The primetime football telecast will visit the San Francisco 49ers new home for the first time in its two-year history.

And it just so happens that the game will also kick off the team's 2015 regular season schedule.

The 49ers will host the Minnesota Vikings at 7:20 p.m. PT on Sept. 14 to close out the NFL's Week 1 slate. The Levi's® Stadium tilt will be the second of two matchups on ESPN that night.

As every Faithful will recall, the last time the team hosted a game on Monday night was the final game at Candlestick Park.

The 49ers defeated the Atlanta Falcons, 34-24, in Week 16 to clinch a playoff spot. NaVorro Bowman ran into history when he intercepted Matt Ryan late in the fourth quarter and returned the ball 89 yards for a touchdown. The play would be known as "The Pick at the 'Stick."

Last season, the 49ers visited the St. Louis Rams on Monday night in Week 6, overcoming an early 14-point deficit to defeat their division rivals, 31-17. Colin Kaepernick threw for a season-high 343 yards and three touchdowns.

This will mark the 72nd time the 49ers appear on "Monday Night Football." Only the Dallas Cowboys and Miami Dolphins have appeared more times. San Francisco, however, has the most wins in NFL history on Monday night with 46.

The 49ers are 19-12-1 all-time in home regular season openers. The team has won its last four Week 1 contests overall, defeating the Cowboys in Dallas last year, 28-17.

Levi's® Stadium and the 49ers played host to three primetime games last season: the Chicago Bears on Sunday night in Week 2, the Seattle Seahawks on Thanksgiving night in Week 13 and the San Diego Chargers on Saturday night in Week 16.

The matchup against the Vikings features a number of on-field storylines as well.

The game will mark Jim Tomsula's first game in his second stint as head coach of the 49ers – he won one game as an interim coach in 2010. Free-agent acquisition Jerome Simpson and cornerback Chris Cook will be facing their former team. Vikings All-Pro running back Adrian Peterson, barring a trade, will be making his first NFL appearance since Week 1 of last season.

The 49ers are 22-22-1 all-time versus the Vikings but have lost each of the last three regular season meetings – the most recent coming in 2012. San Francisco's biggest win over Minnesota came in the 1998 playoffs, as the 49ers beat the Vikings 34-9 en route to winning the organization's fifth Super Bowl.