The San Francisco 49ers and the rest of the league will learn their schedules on Thursday, May 12. The full schedule announcement will air on NFL Network's "Schedule Release '22" at 5 p.m. PT with analysts breaking down the 2022 NFL regular season schedule by division and picking their top matchups and primetime games. The 49ers full 2022 schedule will also be announced on 49ers.com, the 49ers mobile app and 49ers social media channels at that time.
Ahead of the release of the full 2022 NFL regular season schedule on May 12, the following games will be announced:
| Event | Announcement Date |
|---|---|
| First NFL "Thursday Night Football" matchup on Prime Video | Thursday, April 28 (during first round of 2022 NFL Draft) |
| International NFL games | Wednesday, May 4 |
| Select NFL matchups | Week of May 9 |
| 49ers first home game opponent | Thursday, May 12 (3 p.m. PT) |
| Full 2022 NFL Schedule | Thursday, May 12 (5 p.m. PT) |
While fans still have to wait until next month for the schedule, the 49ers 2022 opponents are already set. The 49ers will host games against the Arizona Cardinals, Los Angeles Rams, Seattle Seahawks, Kansas City Chiefs, Los Angeles Chargers, Miami Dolphins, New Orleans Saints, Tampa Bay Buccaneers and Washington Commanders and they will play road games against the Arizona Cardinals, Los Angeles Rams, Seattle Seahawks, Atlanta Falcons, Carolina Panthers, Chicago Bears, Denver Broncos and Las Vegas Raiders.
Check out the 49ers home and away matchups for the 2022 season.
Last meeting at home: November 7, 2021
Score: Cardinals 31 - 49ers 17
49ers lead all-time series 32-29-0
Last meeting at home: November 15, 2021
Score: 49ers 31 - Rams 10
49ers lead all-time series 75-68-3
Last meeting at home: October 3, 2021
Score: Seahawks 28 - 49ers 21
Seahawks lead all-time series 30-17-0
Last meeting at home: November 6, 2016
Score: Saints 41 - 49ers 23
49ers lead all-time series 49-27-2
Last meeting at home: October 23, 2016
Score: Buccaneers 34 - 49ers 17
49ers lead all-time series 18-7-0
Last meeting at home: October 5, 2014
Score: 49ers 22 - Chiefs 17
All-time series tied 7-7-0
Last meeting at home: December 20, 2014
Score: Chargers 38 - 49ers 35
Chargers lead all-time series 8-7-0
Last meeting at home: October 11, 2020
Score: Dolphins 43 - 49ers 17
Dolphins lead all-time series 8-6-0
Last meeting at home: December 13, 2020
Score: Commanders 23 - 49ers 15
49ers lead all-time series 21-12-1
Last meeting in Arizona: October 10, 2021
Score: Cardinals 17 - 49ers 10
49ers lead all-time series 32-29-0
Last meeting in Los Angeles: January 30, 2022
Score: Rams 20 - 49ers 17
49ers lead all-time series 75-68-3
Last meeting in Seattle: December 5, 2021
Score: Seahawks 30 - 49ers 23
Seahawks lead all-time series 30-17-0
Last meeting in Atlanta: December 18, 2016
Score: Falcons 41 - 49ers 13
49ers lead all-time series 48-32-1
Last meeting in Carolina: September 18, 2016
Score: Panthers 46 - 49ers 27
Panthers lead all-time series 13-9-0
Last meeting in Denver: October 19, 2014
Score: Broncos 42 - 49ers 17
49ers lead all-time series 8-7-0
Last meeting in Oakland: December 7, 2014
Score: Raiders 24 - 49ers 13
All-time series tied 7-7-0
Last meeting in Chicago: October 31, 2021
Score: 49ers 33 - Bears 22
49ers lead all-time series 35-32-1
Here's a breakdown of how each team's opponents are set:
- Six games against divisional opponents — two games per team, one at home and one on the road.
- Four games against teams from a division within its conference — two games at home and two on the road.
- Four games against teams from a division in the other conference — two games at home and two on the road.
- Two games against teams from the two remaining divisions in its own conference — one game at home and one on the road. Matchups are based on division ranking from the previous season.
- The 17th game, which was added to the NFL calendar in 2021, is played against a non-conference opponent from a division that the team is not scheduled to face. Matchups are based on division ranking from the previous season.
