San Francisco closed out the 2026 preseason with an 18-12 win over Las Vegas, highlighted by Eddy Piñeiro's perfect night.

Cowing's 83-yard punt return touchdown against the Chargers was a full-circle moment for his journey defined by perseverance and overcoming setbacks.

Highlighting TE George Kittle's remarkably early return to practice, the return of running backs Kaelon Black and Jordan James, and the 49ers preseason finale against the Raiders ahead of final roster cuts.

See what Kyle Shanahan and Chargers head coach Jim Harbaugh had to say following the Preseason Week 2 contest.

San Francisco's preseason win over the Chargers featured big plays from the special teams unit, a productive ground game, and a strong defensive showing.

Check out the biggest plays from the San Francisco 49ers vs. Los Angeles Chargers Preseason Week 2 contest at SoFi Stadium.

View photo highlights from the San Francisco 49ers Preseason Week 2 matchup vs. the Los Angeles Chargers at SoFi Stadium.

San Francisco 49ers head coach Kyle Shanahan provided updates on OL Austen Pleasants, LB Nick Martin, and more, praised WR Jacob Cowing's explosive punt return, and discussed the ongoing competition at left guard.

San Francisco 49ers LB Tatum Bethune wraps up Los Angeles Chargers quarterback DJ Uiagalelei for a five-yard sack.

San Francisco 49ers RB Khalil Herbert rushes for a one-yard touchdown against the Los Angeles Chargers.

San Francisco 49ers QB Adrian Martinez throws a 17-yard touchdown pass to WR Jordan Watkins.

San Francisco 49ers QB Adrian Martinez makes Los Angeles Chargers defenders miss on a nine-yard scoring scramble.

San Francisco 49ers RB Sincere McCormick bursts into the end zone for a seven-yard touchdown rush.

San Francisco 49ers RB Sincere McCormick breaks free up the sideline for a 37-yard rushing gain.

San Francisco 49ers kicker Eddy Piñeiro's 45-yard field goal attempt is good against the Los Angeles Chargers.

San Francisco 49ers quarterback Mac Jones throws a dime to wide receiver KhaDarel Hodge for a 20-yard gain.

San Francisco 49ers QB Mac Jones' 24-yard loft locates WR Jordan Watkins.

San Francisco 49ers wide receiver Jacob Cowing breaks loose down the sideline for an 83-yard punt return touchdown.

San Francisco 49ers kicker Eddy Piñeiro's 48-yard field goal attempt against the Los Angeles Chargers is good.

San Francisco 49ers QB Mac Jones pinpoints a 21-yard pass to WR De'Zhaun Stribling through multiple Chargers defenders.