History: 49ers at Patriots
- San Francisco owns the overall series record vs. New England, 8-5, including a 4-3 record versus the Patriots on the road.
- The 49ers will travel to New England for the first time since 2012, when they defeated the Patriots, 41-34, on NBC's Sunday Night Football.
Players and Coaches to Know:
49ers
- Head Coach: Kyle Shanahan
- Quarterback: Jimmy Garoppolo
- Running Back: Raheem Mostert
- Cornerback: Richard Sherman
Patriots
- Head Coach: Bill Belichick
- Quarterback: Brian Hoyer or Jarrett Stidham
- Running Back: James White
- Cornerback: Stephon Gilmore
