Gore played 16 seasons in the NFL (2005-20), spending ten seasons with the San Francisco 49ers (2005-14). Throughout his time in San Francisco, Gore started in 134 games at running back. He finished his 148-game career with the 49ers with 2,442 carries for 11,073 yards and 64 touchdowns on the ground, adding 342 receptions for 2,883 yards and 11 touchdowns through the air. Gore holds the all-time franchise records for the most 100-yard rushing games (39), most 1,000-yard seasons (8), most rushing touchdowns (64), most rushing yards in a single season (1,695) and all-time rushing yards (11,073). In 2024, Gore was inducted into the Edward J. DeBartolo Sr. 49ers Hall of Fame.