The San Francisco 49ers return home to face Aaron Rodgers and the unbeaten Green Bay Packers at Levi's® Stadium.
San Francisco has won each of the last four meetings, including two in the postseason. All of those victories have come since 2012.
The Packers are traveling across the country on a short week after defeating the Kansas City Chiefs on Monday night. The 49ers have lost two consecutive games, but they won their home opener in Week 1 versus the Minnesota Vikings.
Here are the experts' picks from around the web for the Week 4 clash. Give us your predictions in the comment section below...
Pete Prisco of CBS Sports: Packers 34, 49ers 16
"The Packers are the best team in the league and have the best quarterback. The 49ers are struggling in large part because their quarterback is struggling. Colin Kaepernick has to be better. The Packers play on a short turnaround, so that could factor."
Pete Schrager of Fox Sports: 49ers 31, Packers 28
Check out photos from the 49ers previous meetings against the Green Bay Packers.
"The media pile-on of Colin Kaepernick has hit its apex. You'd think he'd never completed a pass before the way people have been writing and talking about him this week. I'd say to be patient before burying Kaepernick and these 49ers. Bad losses happen. It's how you respond that matters. I've seen Kaepernick destroy Dom Capers' Packers defenses enough to know anything's possible. This is your upset special."
Elliot Harrison of NFL.com: Packers 34, 49ers 13
"This matchup has provided so many beauties through the years. Personal favorite: in the Divisional Round of the 1995 playoffs, when Green Bay walked into Candlestick an underdog and was up 21-0 before you could blink."
Mike Florio of Pro Football Talk: Packers 38, 49ers 23
"The 49ers beat the Packers twice in 2012 and twice in 2013. The Packers haven't forgotten that."
ESPN's panel of 13 experts: 13 pick Packers, zero pick 49ers
USA TODAY's panel of seven experts: seven pick Packers, zero pick 49ers