PHILADELPHIA -- What started as a defensive struggle ballooned into a blowout as the Philadelphia Eagles topped the San Francisco 49ers 33 to 10 in Week 8.

Several notable injuries headlined the 49ers eighth-straight loss.

Here are this week's takeaways from a wet and dreary day at Lincoln Financial Field.

1. The 49ers roster continues to be devastated by injuries. Jimmie Ward (forearm), Garry Gilliam (knee), D.J. Jones (knee), Solomon Thomas (knee) and Joe Staley (eye) all left the game and did not return. That's an absolutely ridiculous list of prominant names. I'm not sure I've ever seen so many guys go down in one game with potentially serious injuries.

Staley was the recipient of a vicious block on the return of an Eagles pick-six. He sustained a gash under his left eye. With Trent Brown inactive, the 49ers finished the game with Zane Beadles at left tackle and Erik Magnuson at right tackle.

2. A few rookies had career-firsts on Sunday. Ahkello Witherspoon intercepted Carson Wentz in the third quarter, which led to Matt Breida's first-career touchdown. Witherspoon started over Rashard Robinson and played the entire game. He was rewarded when Wentz' pass on 3rd-and-14 came right to Witherspoon.

Two plays later, Breida took a shovel pass from C.J. Beathard into the end zone for a 21-yard score. It was a well-designed play by Kyle Shanahan to negate Philadelphia's pressure. He had plenty of space upon catching the ball and made a sprint for the goal line. Breida finished with four catches for 39 yards and 17 yards on five carries.

3. Outside of Breida's touchdown, the offense struggled mightily. Beathard was under constant siege as the Eagles sacked the rookie four times and hit him on several other occasions. The quarterback threw for 167 yards and one touchdown but also threw two interceptions, including the pick-six mentioned above.

Beathard was also the 49ers leading rusher with 40 yards on six carries. Pierre Garçon ran the ball 12 times for just 25 yards. The offense as a whole converted on just 3-of-15 third-down attempts.

4. San Francisco's defense played well early on but the dam broke as the game wore on. Wentz' biggest play of the day was a 53-yard touchdown to Alshon Jeffery. Zach Ertz also had four catches for 34 yards and a touchdown. LaGarrette Blount ran the ball 16 times for 48 yards and a touchdown. Corey Clement led the Eagles with 54 yards on 10 carries.

5. Leger Douzable had two sacks on Sunday in what was his first-career two-sack game. Earl Mitchell added a third sack.

6. Reuben Foster, who was listed as questionable with ankle and rib injuries, did not play against the Eagles.