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49ers to Face Cardinals on 'MNF' in Mexico City

The National Football League announced on Wednesday the opponents and dates for its five 2022 international regular-season games – three in the UK, one in Germany and one in Mexico.

The 2022 international games will feature four playoff participants, including the NFC North champion Green Bay Packers and NFC South champion Tampa Bay Buccaneers, and an NFC West showdown in Mexico.

The 2022 international games:

Table inside Article
Location Matchup Stadium Column 4 Column 5
Mexico 49ers vs. Cardinals Estadio Azteca November 21, 5:15pm PT ESPN
United Kingdom Vikings vs. Saints Tottenham Hotspur Stadium October 2, 6:30am PT NFL Network
United Kingdom Giants vs. Packers Tottenham Hotspur Stadium October 9, 6:30am PT NFL Network
United Kingdom Broncos vs. Jaguars Wembley Stadium October 30, 56:30am PT NFL Network
Germany Seahawks vs. Buccaneers FC Bayern Munich Stadium November 13, 6:30am PT NFL Network

Last year, as part of the League's expansion of the regular season to 17 games, it was determined that, beginning with the 2022 season, up to four of the teams from the conference whose teams were eligible for a ninth regular-season home game would instead be designated to play a neutral-site international game each year.

The NFL will return to Mexico City on November 21 with Monday Night Football. Estadio Azteca will host a matchup between NFC West rivals San Francisco 49ers and Arizona Cardinals in a rematch of the NFL's first regular-season game played outside the United States. In 2005, the teams played at Estadio Azteca with 103,467 fans in attendance, the eight largest crowd in NFL history.

As part of the NFL's new International Home Marketing Area initiative, the 49ers were granted marketing and commercial rights in Mexico and the United Kingdom at least through the 2026 season. Levi's and United Airlines are the first official 49ers partners in both Mexico and the UK.

Learn more about the 49ers game in Mexico City and to sign up for updates, please visit

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