McCaffrey's Touchdown Run Lights Up 'MNF'

Watch the best plays from San Francisco 49ers RB Christian McCaffery's 142-yard game against the Carolina Panthers in Week 12 of the 2025 NFL season.

Check out the San Francisco 49ers biggest moments and game-changing plays from their Week 12 win over the Carolina Panthers.

Head Coach Kyle Shanahan highlighted standout performances on both sides of the ball, and emphasized the growth and execution of the 49ers through a hard-fought "Monday Night Football" victory against Carolina.

San Francisco 49ers S Ji'Ayir Brown picked off Carolina Panthers QB Bryce Young for the second time on 'Monday Night Football.'

San Francisco 49ers RB Christian McCaffrey punches it in for a 12-yard touchdown against the Carolina Panthers.

San Francisco 49ers QB Brock Purdy dodges multiple Carolina Panthers defenders and picks up a 9-yard first down in the team's Week 12 matchup.

San Francisco 49ers S Ji'Ayir Brown intercepted a pass from Carolina Panthers QB Bryce Young on 'Monday Night Football'.

San Francisco 49ers WR Jauan Jennings battled through Panthers defenders, powering his way into the end zone for a touchdown.

San Francisco 49ers team reporter Briana Jeannel chats with halftime performer Marc Martel ahead of the Panthers vs. 49ers "Monday Night Football" matchup at Levi's® Stadium.

Es hora del duelo estelar de lunes por la noche entre los San Francisco 49ers y Carolina Panthers. Jesús Zárate y Carlos Yustis nos comparten las claves de este partido.

Terminaron las prácticas de la semana para los San Francisco 49ers y Jesús Zárate nos comparte la lista actualizada de jugadores con algún estado de lesión, así como un breve adelanto del partido del lunes por la noche ante los Carolina Panthers.

San Francisco 49ers head coach Kyle Shanahan meets with the media to provide injury and personnel updates before their Week 12 matchup against the Carolina Panthers.

San Francisco 49ers defensive linemen Alfred Collins and C.J. West joined "You've Got Mail" presented by Delta Dental to discuss their Pop Warner memories, Texas and Chicago roots, Bay Area first impressions, food favorites, and what it's like bonding as rookies in the 49ers D-line room.

Esta semana le toca a los San Francisco 49ers jugar hasta el lunes, y por eso, Miguel Pasquel y Alfredo Gutiérrez comentan cómo es la dinámica cuando hay partido en horario estelar, así como lo que podemos esperar del rival.

San Francisco 49ers DB Deommodore Lenoir shares his My Cause My Cleats story, supporting Down syndrome inclusion with Football Camp for the Stars.

San Francisco 49ers OL Austen Pleasants shares his My Cause My Cleats story, supporting limb difference awareness with the Lucky Fin Project.

San Francisco 49ers TE George Kittle revisited the moment he learned about RB Christian McCaffrey joining the team, highlighted head coach Kyle Shanahan's continued growth, and explained the technique and mindset behind his favorite run-game calls.

San Francisco 49ers QB Brock Purdy detailed how his confidence, mobility, and chemistry with his playmakers continue to build heading into Monday night against the Carolina Panthers.

San Francisco 49ers defensive coordinator Robert Saleh and offensive coordinator Klay Kubiak detailed the team's progress in the run game and discussed the mindset needed to carry momentum into their primetime matchup.

Esta semana, los San Francisco 49ers jugarán en lunes por la noche ante los Carolina Panthers, y para prepararnos, Miguel Pasquel nos comparte las claves que definirán este partido.

A Norwegian brother and his Bay Area sister reconnect and celebrate their bond through the 49ers.

KNBR's Justin Allegri joins "The Saloon" to recap the 49ers Week 11 win in Arizona, with a one-on-one interview featuring Brian Robinson Jr., and Panthers reporter Kassidy Hill previews "Monday Night Football" vs. Carolina.

San Francisco 49ers RB Brian Robinson Jr. shares his My Cause My Cleats story, advocating against gun violence with Everytown.

San Francisco 49ers quarterback Brock Purdy answers his most searched questions in a special Toyota 1-on-1, including "why does Brock Purdy wear a long sleeve?" and "how is Brock Purdy doing?"

RB Christian McCaffrey, K Matt Gay, FB Kyle Juszczyk, and LB Curtis Robinson discussed their preparation and focus heading into Monday night against the Carolina Panthers, and discussed executing the game plan, staying mentally sharp, and maintaining consistency across every play.