Trey Lance Lofts the Ball to Trent Sherfield for 41-Yard Gain

Watch some of the 49ers top highlights against the Arizona Cardinals in Week 5 of the 2021 NFL season.

Watch every play from 49ers rookie quarterback Trey Lance's first-career start in Week 5 of the 2021 season.

49ers wide receiver Deebo Samuel caught a pass from quarterback Trey Lance over his defender for 26 yards.

49ers wide receiver Brandon Aiyuk made a one-handed reception over his defender for 26 yards.

49ers wide receiver Deebo Samuel rushed for 13 yards and a touchdown.

49ers defensive back Dontae Johnson forced and then recovered a key fumble of Arizona Cardinals running back Chase Edmonds.

49ers wide receiver Mohamed Sanu Sr. caught a 6-yard pass from quarterback Trey Lance to convert on fourth down.

49ers fullback Kyle Juszczyk went up and over a would-be tackle to gain a first down.

49ers defensive end Nick Bosa sacked Arizona Cardinals quarterback Kyler Murray to move the Cardinals out of field goal range.

Quarterback Trey Lance looked downfield to wide receiver Deebo Samuel to move the chains.

49ers defensive tackle D.J. Jones recorded his first sack of the season against Cardinals quarterback Kyler Murray.

Watch some of the 49ers best highlights from the first quarter of the 2021 season.

Check out the 49ers best plays from the team's Week 4 matchup against the Seattle Seahawks.

Watch every play from 49ers rookie quarterback Trey Lance's second half performance vs. the Seattle Seahawks.

Watch every play from 49ers wide receiver Deebo Samuel's 156-yard game against the Seattle Seahawks from Week 4 of the 2021 NFL Season.

49ers wide receiver Deebo Samuel muscled through contact for his second touchdown of the day.

Trey Lance kept the drive alive, connecting with Deebo Samuel for an 11-yard gain.

Trey Lance launched the ball to a wide open Deebo Samuel for an untouched 76-yard touchdown.

The 49ers defensive line swarmed Russell Wilson with Javon Kinlaw and Dee Ford combining for the QB sack.

49ers defensive lineman Nick Bosa took down Seahawks quarterback Russell Wilson to end the Seattle drive.

To cap off the 49ers first drive of their Week 4 matchup vs. the Seahawks, Jimmy Garoppolo found Ross Dwelley for a 21-yard touchdown grab.

Seahawks quarterback Russell Wilson had nowhere to go as Dee Ford brought him down for the sack.

49ers quarterback Jimmy Garoppolo connected with tight end George Kittle for an 18-yard pickup.

Watch Mitch Wishnowsky's September highlights to celebrate his first-ever NFC Special Teams Player of the Month honor.

Watch the San Francisco 49ers best plays against the Green Bay Packers on "Sunday Night Football."