DeMeco Ryans is in his sixth season with the 49ers and second as the team's defensive coordinator. He spent the previous three seasons (2018-20) as the 49ers inside linebackers coach. Ryans also served as the team's defensive quality control coach in 2017.
In his first season as defensive coordinator, Ryans and the 49ers defense ranked third in the NFL in 2021, allowing 310.0 total yards per game. San Francisco also was sixth in the NFL, surrendering 206.5 passing yards per game. San Francisco saw eight different players record an interception on the season, as CB Emmanuel Moseley finished with a career-high 11 passes defensed and one interception. The Niners forced 22 fumbles on defense in 2021, the most in the NFL and the most in a single season by the 49ers since 1994. DL Nick Bosa finished the season leading the team with a career-high 15.5 sacks. His sack total ranked fourth in the NFL among all players as he was selected to the Pro Bowl. DL Arden Key also registered a career-high 6.5 sacks on the year.