A disappointed but resolute Jim Harbaugh let us in on six important nuggets of news before the team started its return trip to San Francisco.
The night belonged to Peyton Manning, and San Francisco's injury-depleted defense struggled to contain the record-breaking quarterback.
The San Francisco 49ers tried to make it a close game with a second-quarter comeback bid, but Peyton Manning’s pinpoint passes were too much to defend in this one-sided contest.
49ers.com gets you ready for Week 7 action with 7 storylines to track when the San Francisco 49ers visit the Denver Broncos on "Sunday Night Football."
Jim Harbaugh spoke to the media Sunday following a 42-17 loss to the Denver Broncos about bouncing back, Daniel Kilgore's injury, Tramaine Brock and more.
The San Francisco 49ers lose to the Denver Broncos 42-17 on a night where Broncos quarterback Peyton Manning broke the NFL record for passing touchdowns.