Four 49ers started were listed as questionable on Friday for the team's Sunday matchup with the Seattle Seahawks.
"It's something I'm going to fight through the rest of the season," Brown said. "It's something that could linger."
View: Week 14 Injury Report
Brown, who still feels pain when "twisting and turning" while running, had been replaced in the starting lineup by
"I's just what I'm expected to do, go out and play," Staley said. "Looking back on it, knowing what I know now, I put those guys in a bad situation last week.
"Shoot, it was just a sprain, might as well tape it up. I can play through sprains."
Staley was ruled out of the Rams game following the first series. His knee buckled when he tested it under the supervision of the training staff.
"It still hurts. I'm not saying it doesn't hurt," Staley said. "It's stiff, but it's something I can play through."