James has been active for two of the team's eight games in 2013. James has seven carries for 31 yards on the season.
Earlier in the week, James said he understood the reason for his gameday role.
The 49ers announced the following inactive players in addition to James:
Baldwin was listed as questionable heading into the game with an illness. Veteran
Jacksonville announced the following inactive players:
QB Ricky Stanzi, WR Stephen Burton, CB Jamell Fleming, G Jaques McClendon, T DeMarcus Love, WR Stephen Williams and DT Arby Jones.
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