The two-time Pro Bowl left tackle was injured last week against the St. Louis Rams and did not finish the game. Staley, however, feels like his MCL sprain is "not severe at all."
"They thought I had done some damage to it, but all the results came back positive," Staley told 95.7 The Game.
San Francisco's blindside protector was limited at Thursday's practice, a good sign that he could re-join teammates on Sunday.
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"We’ll see how it responds day-to-day, but yesterday was a good day," Staley said. "I was out there on the practice field, did some individual stuff, so hopefully I can do more today."
"I’m preparing to play on Sunday," the seventh-year pro added. "I anticipate everything going well. I’m getting my mind and body ready."
Staley is also eager to be a part of a rivalry game with Seattle.
Staley commented that the return of
"He’s the best after the catch receiver I’ve seen in the NFL," the left tackle said. "The style he plays, he brings that physical mindset. He brings that mentality to the offense and people feed off that.
"People feed off seeing a receiver downfield, getting a block, making a guy miss or running a guy over. He’s a tremendous competitor. We’re happy to have him back."
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If Staley is unable to go on Sunday, right guard
Staley believes both players are capable of exceling in those roles.
"I was incredibly impressed," Staley said of how both Boone and Looney played in adjusted roles last week against the Rams. "That’s one of the hardest things to do, especially with what Alex Boone did.
"Boone really stepped up and did a tremendous job for this team... (Rams defensive end) Robert Quinn is no cake walk out there. He did a great job of handling him out there."