One highlight: Safety Tim McDonald, who played for both teams, inspired the show-me-the-money line in "Jerry McGuire" in 1993.
The Arizona Cardinals have a fourth different starting quarterback; the St. Louis Rams throw punches; and the Seattle Seahawks dominate on Sunday Night Football.
The San Francisco 49ers head coach spoke with the media on Monday to address his team's approach for the Week 17 finale against the Arizona Cardinals.
In this Monday edition of Niners Daily, we highlight a rookie who seized an opportunity during the San Francisco 49ers Week 16 game against the San Diego Chargers
With two games remaining and needing 196 rushing yards to break into four-digit territory, the running back turned in a vintage performance against the San Diego Chargers
And the San Francisco 49ers quarterback did it in style, running a record-threatening 90 yards on the impressive play in the team's disappointing defeat.
After an overtime loss to the San Diego Chargers, Jim Harbaugh provided updates on what contributed to his team's Week 16 defeat.
The San Francisco 49ers running back explained how the team rushed for a franchise-record 355 yards against the San Diego Chargers.
The San Francisco 49ers safety said that while all defeats are hard to take, the team's Week 16 affair with the San Diego Chargers was especially difficult to handle in the locker room.
Despite jumping out to a 21-point lead at halftime, San Francisco's injured-depleted defense could not hold off San Diego's furious rally.
San Diego Chargers quarterback Philip Rivers throws a pass intended for wide receiver Seyi Ajirotutu and is intercepted by San Francisco 49ers cornerback Perrish Cox.